PMID: 15334835Sep 1, 2004Paper

Effect of omeprazole paste on intragastric pH in clinically normal neonatal foals

American Journal of Veterinary Research
L Chris SanchezAlfred M Merritt

Abstract

To evaluate the efficacy of omeprazole paste, a commonly used antiulcer drug, on intragastric pH in clinically normal neonatal foals. 6 clinically normal foals between 5 and 14 days of age. Intragastric pH was recorded in each foal by use of a disposable antimony pH electrode with internal reference. Values for intragastric pH were recorded every 4 seconds by use of an ambulatory pH monitor. There were two 24-hour recordings of intragastric pH for each foal, with 24 hours between recordings. Foals were not administered any drugs during the first recording. Foals were administered omeprazole paste (4 mg/kg, PO) 1 hour after the start of the second recording. Mean pH was calculated for each hour of each 24-hour recording session. Hourly mean values were compared between the first and second 24-hour recordings. Complete data were obtained from 4 of 6 foals during the first 24-hour recording and 6 of 6 foals during the second 24-hour recording. Foals had significantly higher mean hourly intragastric pH for hours 2 to 22 following omeprazole administration, compared with corresponding hourly pH values in foals during the first recording. Omeprazole paste can effectively increase intragastric pH in clinically normal neonatal foals wi...Continue Reading

References

Jul 1, 1986·Equine Veterinary Journal·J L Becht, T D Byars
Apr 11, 2001·Journal of the American Veterinary Medical Association·L C SanchezA M Merritt
Oct 22, 2002·Journal of the American Veterinary Medical Association·Jorge E NietoJack R Snyder
Aug 9, 2003·Journal of the American Veterinary Medical Association·James A OrsiniGary Smith

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Citations

Mar 7, 2007·New Zealand Veterinary Journal·R J W BellJ K Kingston
Mar 29, 2008·Journal of Veterinary Internal Medicine·L C SanchezA Y Womble
Apr 14, 2010·Journal of Veterinary Internal Medicine·G W SmithD M Foster
Nov 30, 2005·Journal of the American Veterinary Medical Association·Guy D LesterIan D Robertson
Dec 14, 2005·Journal of Veterinary Pharmacology and Therapeutics·E TéllezH Sumano
Dec 18, 2007·Equine Veterinary Journal·L H Javsicas, L C Sanchez
May 19, 2012·Equine Veterinary Journal. Supplement·J R Elfenbein, L C Sanchez
Jul 30, 2005·The Veterinary Clinics of North America. Equine Practice·L Chris Sanchez
Jul 30, 2005·The Veterinary Clinics of North America. Equine Practice·K Gary Magdesian
Jul 30, 2005·The Veterinary Clinics of North America. Equine Practice·Clare A Ryan, L Chris Sanchez
Jun 10, 2005·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·A F AhmedN A Misk
Apr 14, 2012·The Journal of Veterinary Medical Science·Yoshiro EndoYasuhiro Wakui
Sep 30, 2020·Journal of Veterinary Internal Medicine·Jessica C WiseKristopher J Hughes

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