Effect of Ondansetron on Postoperative Shivering After Craniotomy

World Neurosurgery
Houman TeymourianIman Razavian

Abstract

Postoperative shivering (POS) is an early complication after craniotomy. Preventive pharmacologic drugs are the mainstay of treatment. Meperidine is the drug of choice but with increased risk of apnea, nausea, and increased intracranial pressure. Some reports have suggested that ondansetron and meperidine have similar anti-shivering effects. To assess the preventive effect of ondansetron on POS after craniotomy. In a randomized, double-blind, placebo-controlled trial, 80 patients with American Society of Anesthesiologists status I to II between 20 and 60 years of age scheduled for elective craniotomy were enrolled in the study. Patients received either intravenous ondansetron 4 mg (n = 40) or saline (n = 40) 10 minutes before the end of surgery. POS was observed in 3 patients (7.5%) in the ondansetron group, significantly lower than in the control group (6 patients [15%]; P =0.048). Ondansetron decreased the relative risk of occurrence of POS after craniotomy from 4.42 (95% confidence interval [CI], 2.3-8.5; P = 0.0021) in the control group to 1.05 (95% CI, 0.76-2.20; P = 0.074). In the ondansetron group, the mean (± standard deviation) core temperature in the preoperative phase (36.6°C ± 0.66°C) was significantly higher than i...Continue Reading

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Citations

Nov 20, 2016·The Journal of International Medical Research·Chengmao ZhouLin Ruan
Mar 21, 2020·Iranian Journal of Biotechnology·Elham BehdaniJamal Fayazi
Sep 16, 2016·Journal of Clinical Pharmacology·Wen WangLi Sun
Oct 20, 2020·The Cochrane Database of Systematic Reviews·Stephanie WeibelPeter Kranke

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