Effect of one-month treatment with nonsteroidal antiinflammatory drugs (NSAIDs) on gastric pH of rheumatoid arthritis patients

Digestive Diseases and Sciences
V SavarinoG Celle

Abstract

The use of NSAIDs is strongly associated with peptic ulceration. The inhibition of prostaglandin synthesis with the consequent increase of gastric acidity is considered a possible mechanism. Therefore we decided to assess the effect of one-month treatment with NSAIDs on the circadian gastric pH of rheumatoid arthritis (RA) patients. We studied 11 consecutive patients (one man and 10 women, median age 55, range 26-72 years) with confirmed RA. None was H. pylori positive. A 24-hr gastric pH recording was performed both in basal conditions and after one-month treatment with either indomethacin 150 mg/day (eight cases) or ketoprofen 300 mg/day (three cases). Only the 10 female patients were eligible for final analysis, and six matched healthy subjects not taking NSAIDs were used as control group. The number of 24-hr pH readings for various pH thresholds was calculated for both populations. The highest acid levels (pH < 3.0) did not differ between the two pH profiles of the control group (7440 vs 7391, P = NS), while they predominated after the one-month NSAID treatment (10,339 vs 11,440, P < 0.001) in RA patients. These findings show that there is an increased gastric acidity after one-month of treatment with NSAIDs in female patie...Continue Reading

Citations

Feb 4, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Jørgen Naesdal, Kurt Brown
Feb 6, 2009·Drugs·Marco Lazzaroni, Gabriele Bianchi Porro
Nov 1, 2008·Therapeutic Advances in Gastroenterology·Yoshikazu Kinoshita, Shunji Ishihara
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Aug 13, 2009·Digestive Diseases and Sciences·Masafumi NishinoTakahisa Furuta
Apr 21, 2021·Pain and Therapy·Alberto MagniDiego Fornasari

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