Effect of one-month treatment with vaginal promestriene on serum estrone sulfate levels in cancer patients: a pilot study

Maturitas
Lino Del PupG Corona

Abstract

Vaginal promestriene was tested in gynecological cancer patients who suffered from severe vaginal dryness and dyspareunia. This form of estrogen has a low level of vaginal absorption and proved to be effective for vaginal atrophy. 17 patients were treated with a 10mg soft vaginal suppository daily for one month. Plasma levels of estrone sulfate (E1S), used as the marker of overall estrogenicity, were measured by liquid chromatography in combination with mass spectrometry. Mean E1S levels changed from 533 (22-2920) to 374 (81-856) pg/ml (p=0.39). In highly symptomatic gynecological cancer patients the level of circulating estrone sulfate was not significantly affected by vaginal promestriene treatment overall, but a wide range of levels was noted pre and post treatment in individual patients.

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Citations

Dec 19, 2013·Anti-cancer Drugs·Lino Del PupAdolf E Schindler
Jul 23, 2015·Clinical Breast Cancer·Nicoletta BigliaRossella E Nappi
Aug 24, 2013·International Journal of Pharmaceutics·D SalmonF Pirot
Apr 12, 2014·Maturitas·Rafael Sánchez-BorregoNicolás Mendoza
Feb 16, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Lino Del PupG Scambia
Nov 2, 2020·Journal of Clinical Immunology·Aurore BillebeauUNKNOWN French National Reference Center for Hereditary Angioedema (CREAK)
May 5, 2021·Journal of Menopausal Medicine·Gokcen IlhanUnal Erkorkmaz
Jun 26, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Faustino R Pérez-LópezColleen K Stockdale
Nov 24, 2021·Climacteric : the Journal of the International Menopause Society·S PalaciosM Lilue

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