Effect of Ono-EI-600 elastase inhibitor on high-tidal-volume-induced lung injury in rats.

Journal of Anesthesia
Yasuki FujitaMasaji Nishimura

Abstract

We tested the effect of Ono-EI-600, an elastase inhibitor that suppresses cytokine release, on ventilator-induced lung injury in a rat model. After Wistar rats (aged 8-11 weeks) were anesthetized and tracheostomized, they were randomly assigned to four groups: high tidal volume (V(T)) group (H group: n = 10) receiving peak inspiratory pressure (PIP) 30 cmH(2)O for 240 min; high V(T) with drug group (HD group: n = 10) receiving the same ventilation settings as H group and also intravenous infusion 10 mg x kg(-1) x h(-1) of Ono-EI-600 during the protocol; the lower V(T) group (L group: n = 5) receiving PIP 10 cmH(2)O for 240 min; and control group (C group: n = 5) receiving the same ventilation as L group for 30 min. The cytokine levels (IL-6 and CINC-1) in the bronchoalveolar lavage fluid (BALF) of the H group were significantly higher than those of the C and L groups (P < 0.05). However, for the H and HD groups, no differences were found in arterial blood gas data, cytokine levels in BALF, and histological injury scores. Our experiment provided no evidence that elastase inhibitor Ono-EI-600 protects against lung injury induced by high V(T) ventilation.

References

Jul 1, 1992·Journal of Applied Physiology·Z FuJ B West
Jul 1, 1972·Journal of Applied Physiology·S W Woo, J Hedley-Whyte
Jan 1, 1993·Critical Care Medicine·J C ParkerK J Peevy
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·A N von BethmannS Uhlig
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·D Dreyfuss, G Saumon
Oct 1, 1998·The American Journal of Physiology·M M ReddyP M Quinton
Aug 19, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·N TomizawaY Morishita
May 4, 2000·The New England Journal of Medicine·UNKNOWN Acute Respiratory Distress Syndrome NetworkArthur Wheeler
May 4, 2000·The New England Journal of Medicine·L B Ware, M A Matthay
Apr 24, 2001·American Journal of Respiratory and Critical Care Medicine·J D RicardG Saumon
Sep 11, 2001·American Journal of Respiratory and Critical Care Medicine·W L Lee, G P Downey
Sep 12, 2002·European Journal of Pharmacology·Kazuhito KawabataShozo Matsuoka
Dec 5, 2002·The Journal of Clinical Investigation·John A BelperioRobert M Strieter
Apr 12, 2003·Critical Care Medicine·Roy G Brower, Gordon D Rubenfeld
May 29, 2003·American Journal of Respiratory and Critical Care Medicine·Didier DreyfussGeorges Saumon
Jun 10, 2003·Critical Care Medicine·Christopher H GossUNKNOWN ARDS Network
Aug 3, 2004·Critical Care Medicine·Bernhardt G ZeiherUNKNOWN STRIVE Study Group
Oct 13, 2004·Pulmonary Pharmacology & Therapeutics·Shouetsu TamakumaTaira Abiru
Feb 17, 2005·Pulmonary Pharmacology & Therapeutics·Shinhiro TakedaUNKNOWN Japan Society of Respiratory Care Medicine

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Citations

Apr 4, 2014·Critical Care : the Official Journal of the Critical Care Forum·Joerg KrebsThomas Luecke
Jun 30, 2007·European Journal of Pharmacology·Akihiro SakashitaMitsuhiro Yokoyama

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