Effect of oocyte donor stimulation on recipient outcomes: data from a US national donor oocyte bank.

Human Reproduction
Heather S HippJessica B Spencer

Abstract

How does ovarian stimulation in an oocyte donor affect the IVF cycle and obstetric outcomes in recipients? Higher donor oocyte yields may affect the proportion of usable embryos but do not affect live birth delivery rate or obstetric outcomes in oocyte recipients. In autologous oocyte fresh IVF cycles, the highest live birth delivery rates occur when ~15-25 oocytes are retrieved, with a decline thereafter, perhaps due to the hormone milieu, with super-physiologic estrogen levels. There are scant data in donor oocyte cycles, wherein the oocyte environment is separated from the uterine environment. This was a retrospective cohort study from 2008 to 2015 of 350 oocyte donors who underwent a total of 553 ovarian stimulations and oocyte retrievals. The oocytes were vitrified and then distributed to 989 recipients who had 1745 embryo transfers. The primary outcome was live birth delivery rate, defined as the number of deliveries that resulted in at least one live birth per embryo transfer cycle. The study included oocyte donors and recipients at a donor oocyte bank, in collaboration with an academic reproductive endocrinology division. Donors with polycystic ovary syndrome and recipients who used gestational carriers were excluded. T...Continue Reading

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Citations

Oct 14, 2020·Human Reproduction·Guido Pennings
Mar 21, 2021·Human Reproduction Update·Francisca MartinezNikolaos P Polyzos
Apr 3, 2021·Journal of Assisted Reproduction and Genetics·Jennifer F KawwassBrad Van Voorhis
Jul 31, 2021·Reproductive Biomedicine Online·Vanessa PataiaKamal K Ahuja

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