Effect of opioid-free anaesthesia on post-operative period in cardiac surgery: a retrospective matched case-control study

BMC Anesthesiology
Pierre-Grégoire GuinotBelaid Bouhemad

Abstract

No study has been conducted to demonstrate the feasibility of an opioid-free anesthesia (OFA) protocol in cardiac surgery to improve patient care. The aim of the present study was to evaluate the effect of OFA on post-operative morphine consumption and the post-operative course. After retrospectively registering to clinicaltrial.gov (NCT03816592), we performed a retrospective matched cohort study (1:1) on cardiac surgery patients with cardiopulmonary bypass between 2018 and 2019. Patients were divided into two groups: OFA (lidocaine, dexamethasone and ketamine) or opioid anaesthesia (OA) (sufentanil). The main outcome was the total postoperative morphine consumption in the 48 h after surgery. Secondary outcomes were rescue analgesic use, a major adverse event composite endpoint, and ICU and hospital length of stay (LOS). One hundred ten patients were matched (OFA: n = 55; OA: n = 55). On inclusion, demographic and surgical data for the OFA and OA groups were comparable. The total morphine consumption was higher in the OA group than in the OFA group (15 (6-34) vs 5 mg (2-18), p = 0.001). The pain score during the first 48 post-operative hours did not differ between the two groups. Creatinine values did not differ on the first po...Continue Reading

References

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Oct 21, 2018·BMC Anesthesiology·Vivien BerthoudBelaid Bouhemad
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Mar 1, 2019·European Journal of Anaesthesiology·Francis Veyckemans

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Citations

May 1, 2020·Seminars in Cardiothoracic and Vascular Anesthesia·Nathan ClendenenNathaen Weitzel
May 22, 2020·Journal of Cardiothoracic and Vascular Anesthesia·Antonio PisanoGiovanni Landoni
Feb 17, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Cédrick ZaouterFrançois Martin Carrier
Oct 19, 2020·Journal of Cardiothoracic and Vascular Anesthesia·Jason OchrochJesse Raiten
Jun 19, 2021·Deutsches Ärzteblatt International·Christine H Meyer-Frießem
Feb 18, 2021·Deutsches Ärzteblatt International·Felix BartholmesChristine H Meyer-Frießem

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Methods Mentioned

BETA
sedation

Clinical Trials Mentioned

NCT03816592

Software Mentioned

SPSS

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