EFFECT OF OPTIC DISK-FOVEA DISTANCE ON MEASUREMENTS OF INDIVIDUAL MACULAR INTRARETINAL LAYERS IN NORMAL SUBJECTS

Retina
Kunliang QiuMingzhi Zhang

Abstract

To investigate the effect of optic disk-fovea distance (DFD) on measurements of macular intraretinal layers using spectral domain optical coherence tomography in normal subjects. One hundred and eighty-two eyes from 182 normal subjects were imaged using spectral domain optical coherence tomography. The average thicknesses of eight macular intraretinal layers were measured using an automatic segmentation algorithm. Partial correlation test and multiple regression analysis were used to determine the effect of DFD on thicknesses of intraretinal layers. Disk-fovea distance correlated negatively with the overall average thickness in all the intraretinal layers (r ≤ -0.17, all P ≤ 0.025) except the ganglion cell layer and photoreceptor. In multiple regression analysis, greater DFD was associated with thinner nerve fiber layer (6.78 μm decrease per each millimeter increase in DFD, P < 0.001), thinner ganglion cell-inner plexiform layer (2.16 μm decrease per each millimeter increase in DFD, P = 0.039), thinner ganglion cell complex (8.94 μm decrease per each millimeter increase in DFD, P < 0.001), thinner central macular thickness (18.16 μm decrease per each millimeter increase in DFD, P < 0.001), and thinner total macular thickness (1...Continue Reading

References

Jun 1, 1994·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·A G BennettD F Edgar
Jan 2, 2007·Investigative Ophthalmology & Visual Science·Dennis Shun Chiu LamChristopher Kai-Shun Leung
Jun 27, 2007·Investigative Ophthalmology & Visual Science·Christopher Kai-Shun LeungDennis Shun Chiu Lam
Sep 10, 2008·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Brandon J LujanO'Rese Knight
Sep 26, 2008·IEEE Transactions on Medical Imaging·Mona K GarvinMilan Sonka
Mar 13, 2009·IEEE Transactions on Medical Imaging·Mona Kathryn GarvinMilan Sonka
Feb 19, 2010·Investigative Ophthalmology & Visual Science·Seung Woo HongSeong Kyu Im
Oct 19, 2010·American Journal of Ophthalmology·Ana L LoducaMahnaz Shahidi
Aug 30, 2011·Investigative Ophthalmology & Visual Science·Jean-Claude MwanzaUNKNOWN Cirrus OCT Normative Database Study Group
Oct 13, 2011·Investigative Ophthalmology & Visual Science·Sotaro OotoNagahisa Yoshimura
Jul 28, 2012·Investigative Ophthalmology & Visual Science·Victor T KohTin Aung
Jun 12, 2013·Japanese Journal of Ophthalmology·Kazunori Hirasawa, Nobuyuki Shoji
Jun 14, 2013·Investigative Ophthalmology & Visual Science·Nazli DemirkayaFrank D Verbraak
Oct 9, 2015·Seminars in Neurology·Rachel C NolanLaura J Balcer
Nov 7, 2015·PloS One·Andrea SzigetiGábor Márk Somfai
May 5, 2016·Journal of Neurology·Lisanne J BalkAri J Green
Sep 16, 2016·Asia-Pacific Journal of Ophthalmology·Surabhi RuiaTimothy Y Y Lai
Jan 7, 2017·Seminars in Ophthalmology·Rasha BarhamPaolo S Silva

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Citations

Jul 8, 2020·International Ophthalmology·Rino Frisina, Gaia Martini

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