PMID: 11926203Apr 3, 2002Paper

Effect of oral administration of ascorbic acid on insulin sensitivity and lipid profile in obese individuals

Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición
E Martínez-AbundisC E Cabrera-Pivaral

Abstract

The aim of this study was to identify the effect of an oral ascorbic acid (AA) supplement on lipid profile and insulin sensitivity in obese people. A randomized double-blind clinical trial placebo controlled was performed in 16 obese male volunteers [body mass index (BMI) 30-40 kg/m2]. Eight received orally 1 g of AA daily for four weeks and the other eight volunteers received placebo by the same scheme and period of time. Before and after the pharmacological intervention were measured total cholesterol, high-density-lipoprotein (HDL) cholesterol, triglycerides, glucose, creatinine and uric acid. Low-density-lipoprotein (LDL) cholesterol and very-low-density-lipoprotein (VLDL) triglycerides were calculated using formulas. In order to assess insulin sensitivity before and after the intervention, the steady-state glucose (SSG) was calculated from the insulin suppression test modified with octreotide. There were not significant differences in clinical characteristics between both groups. Basal metabolic profile and SSG were similar between both groups. There were not significant differences in both groups between before and after the intervention in metabolic profile and insulin sensitivity. AA did not modify the lipid profile nor...Continue Reading

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Related Papers

The American Journal of Physiology
N ALLEGRETTI, G VUKADINOVIC
Proceedings of the Society for Experimental Biology and Medicine
S BANERJEE, A BANDYOPADHYAY
The American Journal of Clinical Nutrition
M Cummings
Produits pharmaceutiques
L BEZANGER-BEAUQUESNE
Journal of Enterostomal Therapy
C Young
© 2022 Meta ULC. All rights reserved