Effect of oral administration of green tea extract in various dosage schemes on oxidative stress status of mice in vivo

Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences
Hana BártíkováIva Boušová

Abstract

Green tea is a favorite beverage and its extracts are popular components of dietary supplements. The aim of the present in vivo study was to obtain detailed information about the effect of a standard green tea extract (Polyphenon, P), at different doses, on antioxidant enzymes and oxidative stress markers in murine blood, liver, small and large intestine. In all doses, P improved the oxidative stress status via an increased content of plasmatic SH-groups (by 21-67 %). Regarding antioxidant enzymes in tissues, the low dose of P had the best positive effect as it elevated the activity of NADPH quinone reductase in liver and small intestine, thioredoxin reductase in small intestine and hepatic superoxide dismutase. Based on these facts, consumption of green tea seems to be safe and beneficial, while consumption of dietary supplements containing high doses of catechins may disturb oxidative balance by lowering the activity of thioredoxin reductase, glutathione S-transferase, glutathione reductase and superoxide dismutase.

Citations

Nov 21, 2015·Life Sciences·Alessandra BielliAugusto Orlandi
Dec 11, 2019·International Journal of Molecular Sciences·Guo-Yi TangHua-Bin Li
Jun 21, 2019·Antioxidants·Guo-Yi TangHua-Bin Li
Nov 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sofia C LourençoVítor D Alves

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