Effect of oral appliance on circulating leukocyte telomere length and SIRT1 in obstructive sleep apnea

Clinical Oral Investigations
Ching-Chi LinMei-Wei Lin

Abstract

The increased cardiovascular risk seen in patients with obstructive sleep apnea (OSA) may be due to combination of oxidative stress, systemic inflammation and damage to leukocyte telomere length (LTL) seen with aging. Another molecule, Sirtuin 1 (SIRT1), a histone/protein deacetylase, regulates endothelial nitric oxide synthase and is involved in different aspects of cardiovascular disease, aging and stress resistance. The aim of this study was to evaluate the effects of mandibular advancement device (MAD) on the circulating LTL and SIRT1 protein level in peripheral blood mononuclear cells (PBMCs) in patients with OSA. Forty patients with moderately severe to severe OSA who desired MAD and 20 healthy controls were prospectively enrolled. The LTL was measured by quantitative polymerase chain reaction while SIRT1 protein levels in PBMC was assessed using a Sirtuin 1 ELISA Kit. All study subjects underwent baseline sleep study, with OSA patients having repeat testing at 3 months after MAD. Compared to healthy subjects, patients with OSA at baseline had lower LTL and SIRT1 protein levels in PBMC. After 3 months of MAD, 24 OSA patients, designated as MAD responders, median (range) LTL increased from (0.556 [0.393-0.748]) to (0.708 [...Continue Reading

References

Jun 1, 1995·Annals of Medicine·R Busse, I Fleming
Sep 30, 2000·The New England Journal of Medicine·W PankowF W Lohmann
Mar 5, 2002·American Journal of Respiratory and Critical Care Medicine·Mary S M IpKaren S L Lam
May 10, 2002·Nucleic Acids Research·Richard M Cawthon
Jul 18, 2002·American Journal of Respiratory and Critical Care Medicine·Yüksel PekerJan Carlson
Feb 15, 2003·Sleep Medicine Reviews·Lena Lavie
Jun 18, 2004·American Journal of Respiratory and Critical Care Medicine·Maree BarnesRobert J Pierce
Feb 6, 2008·Proceedings of the American Thoracic Society·Terri E Weaver, Ronald R Grunstein
Feb 6, 2008·Proceedings of the American Thoracic Society·Andrew S L ChanPeter A Cistulli
Jan 15, 2009·The Journal of Pathology·Gitte De BoeckPancras C W Hogendoorn
Jan 31, 2009·American Journal of Respiratory and Critical Care Medicine·Laurent SavaleSerge Adnot
Mar 6, 2009·Geriatrics & Gerontology International·Li ZengShigeto Morimoto
Mar 11, 2010·Journal of Atherosclerosis and Thrombosis·Hidetaka OtaYasuyoshi Ouchi
May 1, 2010·Respiratory Medicine·Antonia BarcelóAlvar Agustí
Jul 17, 2012·Biochemical Pharmacology·Hongwei Yao, Irfan Rahman
Jul 28, 2012·Nutrition Reviews·Yasuo Kagawa
Mar 5, 2015·Mechanisms of Ageing and Development·Nicky PietersTim S Nawrot
May 11, 2016·Annals of the American Thoracic Society·Laurent BoyerSerge Adnot
Oct 1, 2016·Oncotarget·Priscila Farias TempakuSergio Tufik
Jan 14, 2017·Sleep & Breathing = Schlaf & Atmung·Pia RiestraSharon K Davis

❮ Previous
Next ❯

Citations

Jun 19, 2019·International Journal of Molecular Sciences·Yung-Che ChenMeng-Chih Lin
Dec 23, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Laetitia S GasparAlexandrina Ferreira Mendes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Related Papers

Clinical Oral Investigations
Ching-Chi LinShwu-Fang Liaw
Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Joachim T MaurerBoris Stuck
© 2022 Meta ULC. All rights reserved