PMID: 8610968Feb 13, 1996Paper

Effect of oral beta interferon on subsequent immune responsiveness

Annals of the New York Academy of Sciences
P A NelsonH L Weiner

Abstract

Oral administration of myelin antigens reduces the incidence and severity of EAE in rat and mouse models and decreases the frequency of MBP-reactive cells and the frequency of attacks in some patients with multiple sclerosis. Low-dose oral tolerance has been shown to be mediated by Th2-type regulatory cells that secrete TGFbeta and IL-4/IL-10. Adjuvants and cytokines may modulate oral tolerance. The addition of betaIFN to the experimental therapy regimen, either orally or by intraperitoneal injection, has been shown to enhance the suppressive effects of oral myelin antigens when either are fed the suboptimal dosing regimen to suppress EAE. The current studies were conducted to elucidate the mechanism of the observed in vivo synergy of betaIFN and antigen feeding. Analysis of the in vitro proliferative response and cytokine production by lymphocytes from fed animals in response to specific antigen in culture shows that the synergistic effect may be related to both independent suppression of the immune response by oral betaIFN and enhanced production of TGFbeta and IL-4/IL-10. There was an unexpected increase in the production of gammaIFN by lymphocytes in vitro after three doses of oral betaIFN in vivo. These observations have i...Continue Reading

References

Feb 1, 1990·Annals of Neurology·A NoronhaM A Jensen
Jan 15, 1988·The Journal of Immunology : Official Journal of the American Association of Immunologists·P J Higgins, H L Weiner
Jan 1, 1982·Immunological Communications·S L Abreu
Jan 1, 1995·Annals of Neurology·B Weinstock-GuttmanR A Rudick
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·H L Weiner
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·A Friedman, H L Weiner
Apr 1, 1993·Neurology·B G Arnason

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Citations

Dec 13, 2006·Clinical & Developmental Immunology·Ana M C Faria, Howard L Weiner
Dec 4, 1998·Springer Seminars in Immunopathology·H L Weiner, Y Komagata
Jun 6, 2000·Advanced Drug Delivery Reviews·J W Simecka
Jan 29, 1999·Research in Immunology·V K Kuchroo, H L Weiner
Jun 7, 2000·Pharmaceutical Science & Technology Today·M W Beilharz
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·W A Tompkins
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J M CumminsS Krakowka
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M Tanaka-KataokaM Kurimoto
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S TakayamaM Kurimoto
Oct 22, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Henry Yim Wu
Feb 5, 2005·American Journal of Veterinary Research·Joseph M CumminsChad G Thompson
Jul 29, 2005·Immunological Reviews·Ana M C Faria, Howard L Weiner
Feb 8, 2002·Nature·Stephen L HoffmanJ Craig Venter
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiu-Min LiHugh A Sampson

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