PMID: 3994509Feb 1, 1985Paper

Effect of oral cadmium administration to female rats during pregnancy on zinc, copper, and iron content in placenta, foetal liver, kidney, intestine, and brain

Archives of Toxicology
B Sowa, E Steibert

Abstract

Cadmium chloride was administered in drinking water at a concentration of 50 ppm cadmium to female rats for 20 days of gestation. The foetuses were then removed from the uteri of the dams. Gestational exposure to oral cadmium resulted in decreased zinc, copper, iron, metallothionein, and thionein-bound zinc content in foetal liver as well as in reduced copper content in placenta and foetal intestine, brain and kidney. Subcellular fractionation of the foetal liver revealed decreased nuclear and cytoplasmic zinc content as well as decreased microsomal iron content. Pregnant rats exposed to oral cadmium revealed decreased serum zinc and iron concentration as well as reduced ceruloplasmin activity. The decreased zinc, copper, and iron content in foetal organs is suggested to be causally connected with the diminished availability of these metals in the maternal circulation.

References

Feb 1, 1979·Environmental Health Perspectives·H G PeteringK L Stemmer
Apr 1, 1979·Environmental Health Perspectives·M R Fox
Dec 15, 1977·Experientia·A J Zelazowski, J K Piotrowski
Jul 1, 1978·Bulletin of Environmental Contamination and Toxicology·L HastingsG P Cooper
Mar 11, 1975·Proceedings of the Society for Experimental Biology and Medicine·W G Pond, E F Walker
Aug 14, 1981·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·L S Hurley
Jan 1, 1983·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·K T SuzukiR Kawamura
Jan 1, 1983·Annual Review of Nutrition·R A DiSilvestro, R J Cousins
Apr 1, 1983·Placenta·P A Di Sant'AgneseR K Miller
Jun 1, 1983·The Science of the Total Environment·P L Hackett, B J Kelman
Feb 1, 1982·Toxicology and Applied Pharmacology·M P WaalkesJ U Bell
Jun 1, 1982·The Journal of Nutrition·R S BeachL S Hurley
Jan 1, 1982·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·M KirchgessnerA Schnegg
Dec 1, 1982·Toxicology and Applied Pharmacology·M H BhattacharyyaD P Peterson
Apr 1, 1981·Toxicology and Applied Pharmacology·A A Levin, R K Miller
Mar 15, 1980·Toxicology and Applied Pharmacology·B J Kelman, B K Walter

Citations

Mar 1, 1988·Neurotoxicology and Teratology·W R Holloway, D H Thor
Nov 1, 1991·Neurotoxicology and Teratology·M R Pelletier, K P Satinder
Mar 15, 2005·Toxicology Letters·Jun-ichi KuriwakiHisao Nishijo
Aug 29, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M M Brzóska, J Moniuszko-Jakoniuk
Feb 22, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Gabriella NotarachilleDaniela Meleleo
Jul 26, 2005·Neurotoxicology and Teratology·Krzysztof LukawskiMaria Sieklucka-Dziuba
Sep 27, 2014·Journal of Applied Toxicology : JAT·Anja MikolićSaša Kralik Oguić
Sep 8, 2016·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Anja MikolićMartina Piasek
Mar 1, 1990·Toxicology and Applied Pharmacology·T L Sorell, J H Graziano
Sep 15, 2005·Journal of Applied Toxicology : JAT·Alejandra Minetti, Carlos A Reale
Feb 1, 1993·Journal of the American College of Nutrition·B R KuhnertP Erhard

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.