PMID: 2106191Jan 1, 1990Paper

Effect of oral clonidine, insulin-induced hypoglycemia and exercise on plasma GHRH levels in short-stature children

Acta Endocrinologica
I Gil-AdZ Laron

Abstract

Human growth hormone release is affected by a variety of pharmacological and physiological stimuli. We have studied the effect of oral clonidine, insulin hypoglycemia, and exercise on plasma hGH and GHRH levels in 31 healthy short-stature children. Thirteen underwent an oral clonidine test (0.15 mg/m2), 12 an iv. insulin test (0.1 U/kg), and 6 performed exercise (running for 10 min in a defined route). GHRH-1-44 was extracted from plasma on silica columns and determined by RIA. Although all three stimuli induced a marked increase in plasma hGH levels, only clonidine induced a significant increase in plasma GHRH levels. Maximal increment in GHRH during clonidine was 6.82 +/- 1.05 pmol/l (mean +/- SEM) as compared with 0.51 +/- 0.28 and 0.53 +/- 0.62 during hypoglycemia and exercise (p less than 0.0005 and p less than 0.005), respectively. An additional 24 subjects received TRH 0.2 mg/kg iv: 8 TRH alone, 8 TRH and insulin, and 8 TRH and clonidine. Only insulin potentiated the TRH-induced TSH response with a peak of 22.0 +/- 3.2 vs 16.0 +/- 0.8 and 15.3 +/- 1.5 mU/l (p less than 0.025) for TRH alone and TRH and clonidine, respectively. It is suggested that clonidine stimulates hGH secretion mainly through an enhancement of GHRH re...Continue Reading

Citations

Oct 1, 1996·Acta Paediatrica Japonica; Overseas Edition·T AsamiM Uchiyama
Feb 15, 1996·The Journal of Clinical Investigation·C A JaffeA L Barkan
Dec 12, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·P C SizonenkoZ Laron
Jan 1, 1996·Journal of Pediatric Endocrinology & Metabolism : JPEM·M G RopelatoC Bergadá
Dec 17, 2010·Journal of Pediatric Endocrinology & Metabolism : JPEM·Inas MazenHala T El-Bassyouni
Jun 1, 1992·Journal of Endocrinological Investigation·S LocheC Pintor

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