Effect of oral immunization with pooled antigens derived from adipose tissue on atherosclerosis and obesity indices

Vaccine
Aldar S Bourinbaiar, Vichai Jirathitikal

Abstract

Modulation of the inflammatory response through vaccination has shown promise in animal models of atherogenesis and obesity-main risk factors for cardiovascular diseases. Tableted preparation, V-6, containing pooled antigens derived from pig adipose tissue was administered per os daily to 13 volunteers for 3 months. Total cholesterol and LDL levels have not changed from the baseline value; 193.4 vs 191.8 (p=0.75) and 113.8 vs 117.2 (p=0.18), respectively. Triglyceride levels declined by 26.1% from 163 to 120.5mg/dL (p=0.29). HDL increased by 25.9% from 38.6 to 48.5mg/dL (p=0.000002) in 12 out 13 patients. Despite negligible effect of V6 on weight and body mass index, i.e., 67.87 vs 66.58 kg (-1.9%; p=0.46) and 26.25 vs 25.75 kg/m(2) (-1.9%; p=0.35), statistically significant reduction in waist (-7.6%; p=0.002), mid-arm (-3.3%; p=0.049), and thigh (-7.6%; p=0.0003) circumferences were observed. Blood pressure systolic and diastolic values were not affected, i.e., 115.6 vs 121 (p=0.2) and 77.1 vs 83 (p=0.55). No changes were observed in liver ALT and AST enzymes. Creatinine decreased; 0.877 vs 0.842 mg/dL (p=0.02), while BUN has shown slight increase; 14.8 vs 16.1mg/dL (p=0.03) but within normal range. Fasting blood sugar levels ...Continue Reading

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Citations

Oct 21, 2011·Thrombosis and Haemostasis·S C A de Jager, J Kuiper
Dec 25, 2013·Human Vaccines & Immunotherapeutics·Mariana P Monteiro
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Apr 24, 2020·Circulation Research·Jan Nilsson, Göran K Hansson
Oct 27, 2021·Endocrine Reviews·Angeliki M AngelidiChristos S Mantzoros

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