Effect of oral L-carnitine administration on insulin sensitivity and lipid profile in type 2 diabetes mellitus patients

Annals of Nutrition & Metabolism
Manuel González-OrtizEsperanza Martínez-Abundis

Abstract

It was the aim of this study to evaluate the effect of oral L-carnitine administration on insulin sensitivity and lipid profile in subjects with type 2 diabetes mellitus. A randomized, double-blind, placebo-controlled clinical trial was carried out in 12 subjects with type 2 diabetes. Six subjects received L-carnitine 1 g orally 3 times a day before meals for a period of 4 weeks. Six other individuals took a placebo for the same period of time, as the control group. Before and after the intervention, insulin sensitivity and the lipid profile were estimated. To assess insulin sensitivity, the euglycemic-hyperinsulinemic clamp technique was performed. Wilcoxon's signed rank and the Mann-Whitney U test were used for the statistical analyses. There were no significant differences in basal clinical characteristics between the 2 groups. Insulin sensitivity and the basal lipid profile were similar. There were no significant changes in either group after the intervention in insulin sensitivity (3.2 +/- 1.2 vs. 4.5 +/- 1.7 mg/kg/min, p = 0.115, and 3.5 +/- 0.6 vs. 3.5 +/- 0.4 mg/kg/min, p = 0.917, for the placebo and L-carnitine groups, respectively) and in lipid profile. L-Carnitine orally administered for a period of 4 weeks did not m...Continue Reading

Citations

Jul 5, 2011·Asian Journal of Andrology·María EncisoJaime Gosálvez
Mar 24, 2011·European Journal of Clinical Nutrition·I ZazpeUNKNOWN SUN Project Investigators
Jan 7, 2010·Nature Reviews. Genetics·Mary Ann Handel, John C Schimenti
Nov 2, 2011·Nutrition & Metabolism·Janine KellerKlaus Eder
Oct 20, 2009·Diabetology & Metabolic Syndrome·Kamal A Amin, Mohamed A Nagy
Apr 7, 2011·Journal of Oral Science·Patricia González-AlvaKaoru Kusama
Aug 19, 2011·European Journal of Clinical Nutrition·P Henríquez SánchezA Sánchez-Villegas
Feb 28, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Monika CahovaLudmila Kazdova
May 15, 2010·JPEN. Journal of Parenteral and Enteral Nutrition·Alessio MolfinoAlessandro Laviano
Apr 21, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Mabrouk Attia Abd EldaimHesham Saad El Sabagh
Aug 8, 2009·Diabetes/metabolism Research and Reviews·Randall L Mynatt
Jul 6, 2019·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Ibrahim A El Sharkwy, Walled M Abd El Aziz
Dec 13, 2019·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Esmaeil Yousefi RadSomayeh Saboori
Jul 15, 2009·British Journal of Pharmacology·Edgars LiepinshMaija Dambrova

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American College of Nutrition
Geltrude MingroneG Gasbarrini
Journal of the American College of Nutrition
A De GaetanoM Calvani
Diabetes/metabolism Research and Reviews
R L Mynatt
© 2022 Meta ULC. All rights reserved