PMID: 7036401Oct 1, 1981Paper

Effect of oral salbutamol and slow-release aminophylline on exercise tolerance in chronic bronchitis

Thorax
A G LeitchG J McHardy

Abstract

In a double-blind placebo-controlled trial in 24 patients fulfilling the MRC criteria for chronic bronchitis, oral salbutamol 4 mg and slow-release aminophylline (Phyllocontin) 450 mg produced similar and significant (p less than 0.05) mean increases in forced expiratory volume in one second (FEV1). A significantly greater increase in mean FEV1 and forced vital capacity (FVC) was seen when both drugs were given although there was no statistical evidence of synergistic interaction. Salbutamol significantly increased the mean distance walked in 12 minutes (12MD) (p less than 0.02) by 56 metres and a similar increase of 54 metres (p less than 0.001) was seen after Phyllocontin. With both drugs in combination mean 12MD increased by 51 metres (p less than 0.02 cf placebo), a change not significantly different from that observed with either drug alone. Oral salbutamol and Phyllocontin improve exercise tolerance in chronic bronchitis. The significantly greater changes in FEV1 and FVC resulting from simultaneous administration of the two drugs are not associated with further improvement in exercise tolerance.

References

Aug 1, 1977·Thorax·I A CampbellA B Kay
Feb 16, 1978·The New England Journal of Medicine·J D WolfeM Simmons
Apr 3, 1976·British Medical Journal·C R McGavinG J McHardy
Sep 17, 1966·Lancet·S Freedman, K Prowse
Feb 23, 1980·British Medical Journal·D J Sinclair, C G Ingram

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Citations

Jan 3, 1987·Lancet·P M Tweeddale, G J McHardy
Sep 1, 1989·Respiratory Medicine·A D Morgan
Jan 1, 1996·Journal of Cardiopulmonary Rehabilitation·B Steele
Jan 15, 1983·British Medical Journal·A D MorganG J McHardy
Dec 15, 1984·British Medical Journal·G M Cochrane
Jan 1, 1983·Postgraduate Medical Journal·H C Thomas
Nov 1, 1984·Thorax·G H GuyattD W Taylor
Sep 1, 1988·The American Review of Respiratory Disease·R Berger, D Smith
May 14, 2010·International Journal of Chronic Obstructive Pulmonary Disease·B Aguilaniu
Jan 1, 1985·Journal of Chronic Diseases·G H GuyattS O Pugsley
Apr 1, 1996·Journal of the American Geriatrics Society·N B Alexander
Jan 10, 2003·The Cochrane Database of Systematic Reviews·F S RamS Cendon
Jan 1, 1983·Postgraduate Medical Journal·D C Flenley

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