Effect of oral sodium bicarbonate supplementation on interdialytic weight gain, plasma sodium concentrations and predialysis blood pressure in hemodialysis patients

Blood Purification
Ezio MovilliGiovanni C Cancarini

Abstract

Correction of metabolic acidosis in dialysis patients should be considered of paramount importance. However, consuming sodium bicarbonate tablets during the interdialytic interval to reach predialysis bicarbonate levels of 23--24 mmol/l is not widespread due to the fear of greater interdialytic weight gain and fluid overload. For this reason we investigated in a cross-sectional and in an interventional study the effect of oral sodium bicarbonate supplementation on body weight gain, plasma sodium concentrations and predialysis blood pressure in a group of stable uremic patients on regular hemodialysis (HD) treatment. 110 patients (67 men, 43 women), mean age 67+/-15 (range 22--89) years, on regular chronic HD treatment for 6--372 (median 48) months were studied. 70 patients were on regular oral bicarbonate supplementation for at least 4 weeks (group A), 40 patients were not on oral bicarbonate supplementation (group B). The following parameters were recorded: dry body weight (DBW), interdialytic weight gain (IWG), body mass index (BMI), plasma sodium (Na), serum pH, serum bicarbonate (sBic), K(t)/V, normalized protein catabolic rate (PCRn), predialysis systolic (SBP) and diastolic (DBP) blood pressure, and bicarbonate therapy (g...Continue Reading

References

Nov 25, 2015·Seminars in Dialysis·David Tovbin, Richard A Sherman
Feb 17, 2009·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Ezio MovilliGiovanni C Cancarini
Oct 18, 2015·Néphrologie & thérapeutique·Jan HavlinKarel Matousovic
Dec 3, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jan HavlinOtto Schück
Sep 26, 2014·International Urology and Nephrology·Alessandra M BalesRosilene M Elias
Nov 18, 2017·Seminars in Dialysis·Qi Qian

Citations

Jan 1, 1995·The Journal of Clinical Investigation·P E BallmerR Krapf
Apr 29, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ezio MovilliR Maiorca
Jul 29, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ezio MovilliR Maiorca
Sep 2, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J UribarriG Yan
Feb 13, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J D Kopple

Related Concepts

Hemodialysis
Diastolic Blood Pressure Measurement
Serum Bicarbonate Measurement
Fluid Overload
Diastolic Blood Pressure
Weighing Patient
Catabolic Process
Uremia
Sodium Bicarbonate
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