PMID: 6407293Jun 1, 1983Paper

Effect of oral sustained-release nitroglycerin on exercise capacity in angina pectoris: dose-response relation and duration of action during double-blind crossover randomized acute therapy

The American Journal of Cardiology
S G DegreP P Vandermoten

Abstract

Ten men with documented coronary artery disease and stable exertional angina underwent a double-blind crossover study to examine the benefit and the duration of action on their symptom-limited exercise capacity of 2 doses (2.5 and 6.5 mg) of sustained-release nitroglycerin (SRNG). A multistage bicycle test was performed in the sitting position by steps of 30 W each 3 minutes until the onset of typical angina pectoris. It was performed 24 hours before the start of the study; 1 and 5 hours after administration of placebo, and repeated after 2.5 and 6.5 mg of SRNG administered in a double-blind crossover study according to a 4 successive days protocol. No differences appeared between administration of placebo (1 and 5 hours) and the results obtained at the first exercise test. The dose of 2.5 mg of SRNG was effective on the symptom-limited working capacity but only at 1 hour (+9%; p less than 0.01). The dose of 6.5 mg was more effective both at 1 hour (+25%; p less than 0.001) and at 5 hours (+27%; p less than 0.001). All patients had angina at a higher heart rate (+5 to 8%; p = NS [not significant] and p less than 0.01), whereas systolic blood pressure and double product tended to be slightly but insignificantly increased. S-T de...Continue Reading

References

Feb 1, 1978·The American Journal of Medicine·J Abrams
Aug 1, 1971·Annals of Internal Medicine

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Citations

Aug 1, 1994·Cardiovascular Drugs and Therapy·U Thadani, R J Lipicky
Jun 19, 2010·International Journal of Cardiology·Jiafu WeiDejia Huang
Nov 1, 1987·Drug Intelligence & Clinical Pharmacy·F P Zeller

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