Effect of oral THC pretreatment on marijuana cue-induced responses in cannabis dependent volunteers

Drug and Alcohol Dependence
Leslie H Lundahl, M K Greenwald

Abstract

The current study tested whether oral Δ(9)-tetrahydrocannabinol (THC: 0-, 10-, and 20-mg) pretreatment would attenuate polysensory cue-induced craving for marijuana. Cannabis dependent participants (7 males and 7 females, who smoked on average 5.4 ± 1.1 blunts daily) completed 3 experimental sessions (oral THC pretreatment dose; counterbalanced order) using a placebo-controlled within-subject crossover design. During each session, participants completed a baseline evaluation and were first exposed to neutral cues then marijuana cues while physiological measures and subjective ratings of mood, craving, and drug effect were recorded. Following placebo oral THC pretreatment, marijuana (vs. neutral) cues significantly increased ratings of marijuana craving (desire and urge to use, Marijuana Craving Questionnaire (MCQ)-Compulsivity scale), anxious mood and feeling hungry. Males also reported feeling more "Down" during marijuana cues relative to females. Pretreatment with oral THC (10-mg and/or 20-mg vs. placebo) significantly attenuated marijuana cue-induced increases in craving and anxiety but not hunger. Oral THC attenuation of the cue-induced increase in MCQ-Compulsivity ratings was observed in females only. Oral THC produced sta...Continue Reading

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Citations

Jan 24, 2016·Frontiers in Neuroendocrinology·Edward J Wagner
Jul 21, 2016·Drug and Alcohol Dependence·Leslie H Lundahl, Mark K Greenwald
Aug 16, 2016·Drug and Alcohol Dependence·Jane MetrikJames MacKillop
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Aug 16, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ziva D Cooper, Rebecca M Craft
Sep 12, 2020·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Philip G TibboDavid N Crockford

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