Effect of ORG 34116, a corticosteroid receptor antagonist, on hippocampal Ca2+ currents

European Journal of Pharmacology
H KarstM Joëls

Abstract

ORG 34116, a substituted 11,21-bisarylsteroid compound, binds selectively and with high affinity to human and rat glucocorticoid receptors. At the level of the hypothalamus it attenuates the negative feedback action of corticosterone, suggesting that it acts as an antagonist. In the present study we examined the effect of in vitro and in vivo administered ORG 34116 on cell properties of higher brain areas, i.e. on Ca2+ current characteristics of CAI hippocampal neurons recorded with whole cell techniques in hippocampal slices. We observed that in vitro applied ORG 34116 antagonized corticosterone induced effects on Ca2+ currents. Data observed after in vivo application of ORG 34116 corroborate these findings. The results furthermore suggest that pretreatment with the glucocorticoid receptor antagonist ORG 34116 also prevents the development of mineralocorticoid receptor mediated effects on Ca2+ currents. If ORG 34116 should indeed prove to be a corticosterone rather than glucocorticoid receptor selective antagonist, this drug may turn out to be an important tool in the treatment of stress-related disorders.

References

Jan 1, 1992·Trends in Neurosciences·M Joëls, E R de Kloet
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D S KerrP W Landfield
Sep 1, 1989·Pflügers Archiv : European journal of physiology·F A EdwardsT Takahashi
Sep 1, 1985·Journal of Steroid Biochemistry·D GagneD Philibert
Jun 1, 1994·Human Reproduction·O HeikinheimoP Lähteenmäki

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Citations

Dec 5, 2002·European Journal of Pharmacology·Marja Van KampenEberhard Fuchs
Nov 15, 2002·Molecular and Cellular Endocrinology·Joost A KoedamSylvia C van Buul-Offers
Sep 13, 2001·The European Journal of Neuroscience·H Karst, M Joëls
Feb 18, 2003·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·O M WolkowitzV I Reus
Jan 18, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Henk Karst, Marian Joëls

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