Effect of orthostatic hypotension on sustained attention in patients with autonomic failure

Journal of Neurology, Neurosurgery, and Psychiatry
P van VlietJ G van Dijk

Abstract

Orthostatic hypotension has been associated with impaired cognitive function, but cognitive function during orthostatic hypotension has hardly been studied. We studied the effect of orthostatic hypotension, induced by head-up tilt (HUT), on sustained attention in patients with autonomic failure. We studied the sustained attention to response task (SART) in the supine position and during HUT in 10 patients with autonomic failure and 10 age-matched and sex-matched controls. To avoid syncope, the tilting angle was tailored to patients to reach a stable systolic blood pressure below 100 mm Hg. Controls were all tilted at an angle of 60°. Cerebral blood flow velocity, blood pressure and heart rate were measured continuously. In patients, systolic blood pressure was 61.4 mm Hg lower during HUT than in the supine position (p<0.001). Patients did not make more SART errors during HUT than in the supine position (-1.3 errors, p=0.3). Controls made 2.3 fewer errors during SART in the HUT position compared to the supine position (p=0.020). SART performance led to an increase in systolic blood pressure (+11.8 mm Hg, p=0.018) and diastolic blood pressure (+5.8 mm Hg, p=0.017) during SART in the HUT position, as well as to a trend towards inc...Continue Reading

References

May 1, 1990·Journal of the American College of Cardiology·M W KronenbergD Robertson
Jul 1, 1995·Mayo Clinic Proceedings·P A LowC A Huck
Apr 27, 1996·Lancet·I SkoogA Svanborg
Jul 18, 2002·Cardiology Clinics·Italo Biaggioni, Rose Marie Robertson
Jan 30, 2003·Psychosomatic Medicine·Thomas W Kamarck, William R Lovallo
Mar 29, 2003·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·A HetzelS Braune
Jul 22, 2005·Lancet Neurology·Chengxuan QiuLaura Fratiglioni
Aug 15, 2006·International Journal of Geriatric Psychiatry·Liesl M AllcockDavid J Burn
Dec 21, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·L M AllanR A Kenny
Feb 10, 2009·Applied Psychophysiology and Biofeedback·Danielle H HernandezMatthew C Whited
Nov 7, 2009·Neuroepidemiology·Kathryn M RoseRebecca F Gottesman
Sep 22, 2010·Journal of the Neurological Sciences·Shima MehrabianOlivier Hanon
Sep 7, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·R PodaP Cortelli
Dec 14, 2011·Archives of Neurology·Christopher H GibbonsRoy Freeman
Nov 28, 2012·Journal of Neurology·Manuela MetzlerGregor K Wenning
Nov 12, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·John FrewenRose Anne Kenny

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
Alexander Y RazumovskyPeter C Rowe
Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
B J RobinsonR H Johnson
© 2022 Meta ULC. All rights reserved