Effect of orthotopic liver transplantation (OLT) on branched-chain amino acid requirement

Pediatric Research
Diana R MagerPaul B Pencharz

Abstract

Little is known regarding the impact of liver transplantation on amino acid requirements in children. Since plasma levels of the branched-chain amino acids (BCAA) are decreased in the presence of normal levels of the aromatic amino acids after liver transplantation, normalization of hepatic function may not fully correct changes in BCAA metabolism that occur in the pretransplant period. The goal of the present study was to determine total BCAA requirements of children following liver transplantation. The requirement of total BCAA was determined using indicator amino acid oxidation (IAAO) in five clinically stable children (5.7 +/- 3.5 y, mean +/- SD) 1-8 y post liver transplantation. Children received in random order 6 graded intakes of total BCAA. Individual BCAA in the test diet were provided in the same proportions as present in egg protein to minimize the potential interactive effects of individual BCAA on assessment of requirement. Total BCAA requirement was determined by measuring the oxidation of L-[1-13C] phenylalanine to 13CO2 [F13CO2 in micromol/kg/h], after a primed, continuous infusion of the tracer and using a two-phase linear regression crossover regression analysis. The estimated average requirement and the upper...Continue Reading

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Dec 21, 2005·The Journal of Nutrition·Diana R MagerPaul B Pencharz

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Citations

Oct 31, 2012·The British Journal of Nutrition·Rajavel ElangoPaul B Pencharz
Nov 17, 2012·World Journal of Gastroenterology : WJG·Xin-Hua ZhuYi-Tao Ding
Jan 8, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Vincent W Lam, Ronnie T Poon
Mar 17, 2012·JPEN. Journal of Parenteral and Enteral Nutrition·Xinhua ZhuYitao Ding
May 18, 2012·The Cochrane Database of Systematic Reviews·Ronald L KoretzTimothy O Lipman
Aug 17, 2012·The Cochrane Database of Systematic Reviews·Gero LangerAstrid Fink
Jul 24, 2018·JPEN. Journal of Parenteral and Enteral Nutrition·Diana R MagerJason Y K Yap
Apr 7, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Sudeep Khanna, Sarath Gopalan
Jan 23, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Poh Hwa OoiDiana R Mager
Jan 22, 2008·The Journal of Nutrition·Rajavel ElangoPaul B Pencharz

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