PMID: 6986794Jan 1, 1980Paper

Effect of osmolality on arginine vasopressin and renin release after hemorrhage

The American Journal of Physiology
R E WeitzmanD A Fisher

Abstract

The effects of alterations of plasma osmolality on plasma arginine vasopressin (AVP) and renin activity (PRA) following graded hemorrhage were studied in conscious dogs who were either euhydrated, dehydrated, water loaded, or infused with hypertonic saline. Base-line plasma osmolality and AVP were significantly different in the four treatment groups; however, following hemorrhage the increases in log AVP did not significantly differ. An unexpected finding was that water loading resulted in significant elevations in PRA and plasma aldosterone concentrations, whereas plasma osmolality and AVP were reduced. Prior to hemorrhage, PRA was significantly greater in the water-loaded and dehydrated groups than in the euhydrated or saline-infused groups; following hemorrhage the increases in log PRA were not significantly different in all four treatment groups. The data suggest that, although alterations in osmolality influence base-line levels of AVP, they have no effect on relative (logarithmic) rises in AVP following hemorrhage. Similarly, alterations in AVP may influence base-line PRA, but do not influence relative rises in PRA following hemorrhage.

References

Sep 6, 1978·Pflügers Archiv : European journal of physiology·M Rocha e SilvaE M Castro de Souza
Nov 1, 1977·Endocrinology·R E WeitzmanR Guillemin
Apr 1, 1976·The Journal of Clinical Endocrinology and Metabolism·G L Robertson, S Athar
Feb 1, 1973·British Journal of Pharmacology·D CousineauP Sirois
Dec 1, 1973·The Journal of Clinical Investigation·F L DunnG L Robertson
Feb 1, 1974·The Journal of Clinical Endocrinology and Metabolism·W R SkowskyD A Fisher
Oct 1, 1971·The Journal of Endocrinology·M L ForslingA M Burton
May 1, 1970·The American Journal of Physiology·J A JohnsonW W Moore
Dec 1, 1968·The American Journal of Physiology·L Share
Oct 1, 1967·Endocrinology·H SachsA Carpi
May 1, 1960·Endocrinology·H WEINSTEINH SACHS

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Citations

Aug 24, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M G ErvinA H Jobe
Jan 1, 1984·European Journal of Applied Physiology and Occupational Physiology·V CandasJ P Libert
Nov 14, 2003·American Journal of Physiology. Endocrinology and Metabolism·Noriko KondoYutaka Oiso

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