Effect of osmolality on mucociliary transportability and rheology of cystic fibrosis and bronchiectasis sputum

Respirology : Official Journal of the Asian Pacific Society of Respirology
Yasuhiro ShibuyaPeter J Cole

Abstract

Water is the main constituent of mucus, and its concentration is likely to be important in all aspects of mucus function, including ciliary clearance. The objective of this study was to investigate the effect of water content and osmolality of the mucus on mucociliary transportability. Rheology and ciliary transportability of 10 sputum samples that had been subjected to various manipulations were measured using a mucus-depleted bovine trachea model. It was shown that addition of sodium chloride 0.2 Osmoles/kg (0.585% weight for weight) increased the transportability by 41% (P < 0.01). Evaporation of the sputum to 50% of its original weight caused a 118% increase in transportability (P < 0.0006), but iso-osmolal removal of 50% of the liquid with filter cards led to a non-significant, 25% increase in transportability. Parallel plate viscoelasticity was approximately doubled in both the evaporated and liquid-depleted samples, but was not changed by the addition of 0.2 Osmoles/kg of sodium chloride. The correlation between the osmolality of sputum and ciliary transportability (r = 0.54, P= 0.005) was better than the correlations between the viscosity (r = 0.21, P= 0.27) or elasticity (r = 0.23, P= 0.23) and ciliary transportability...Continue Reading

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Citations

Jun 29, 2006·Bulletin of Mathematical Biology·D J SmithJ R Blake
Aug 1, 2013·American Journal of Respiratory and Critical Care Medicine·Pamela J McShaneMary E Strek
Feb 10, 2016·Clinics in Chest Medicine·Wael ElMaraachliAngela C C Wang
Feb 22, 2012·Respiratory Medicine·Caroline H H NicolsonAnne E Holland
Jun 7, 2011·Respiratory Medicine·Joana TambascioAda Clarice Gastaldi
May 26, 2017·Expert Review of Respiratory Medicine·Danielle F Wurzel, Anne B Chang
May 13, 2014·The Cochrane Database of Systematic Reviews·Anna HartIain Crossingham
Nov 19, 2010·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Joana TambascioAda Clarice Gastaldi

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