Effect of osteoconductive hyaluronate hydrogels on calvarial bone regeneration

Biomaterials Research
Junseok YeomSei Kwang Hahn

Abstract

Without exploitation of possibly immunogenic and carcinogenic bone morphogenetic protein, we developed simple but clinically feasible artificial bone graft using osteoconductive hyaluronate (HA) hydrogels and bioactive MegaGen synthetic bone (MGSB). HA hydrogels were synthesized by the crosslinking reaction between carboxyl groups of HA and amine groups of gelatin (GEL). Then, artificial bone grafts were prepared by mixing MGSB with HA-GEL hydrogels. The bone regeneration by the MGSB/HA-GEL hydrogel complex was assessed in the skull of New Zealand white male rabbits in 4 and 8 weeks. HA hydrogels were synthesized by the crosslinking reaction between carboxyl groups of HA and amine groups of gelatin (GEL). Then, artificial bone grafts were prepared by mixing MGSB with HA-GEL hydrogels. In vitro proliferation of preosteogenic cells was enhanced with increasing molecular weight of HA. In addition, histological analysis of dissected tissues with hematoxylin and eosin staining confirmed the effective in vivo bone regeneration by the MGSB/HA-GEL hydrogel complex. The MGSB/HA-GEL hydrogels were well resorbed and partially substituted to the lamellar bone after implantation for 8 weeks. The novel artificial bone graft of MGSB/HA-GEL hy...Continue Reading

Citations

Mar 24, 2016·Journal of Biomedical Materials Research. Part a·Ningbo ZhaoDehua Li
May 31, 2018·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·José Nivaldo da SilvaValéria Régia Franco Sousa
Feb 19, 2015·Journal of Biomedical Materials Research. Part a·Sung Chul ChoiChan-Wha Kim
Jun 18, 2021·Biomaterials Research·Seong-Jong KimSei Kwang Hahn

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scanning electron microscopy

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