Effect of Outflow Tract Banding on Embryonic Cardiac Hemodynamics

Journal of Cardiovascular Development and Disease
Venkat Keshav ChivukulaSandra Rugonyi

Abstract

We analyzed heart wall motion and blood flow dynamics in chicken embryos using in vivo optical coherence tomography (OCT) imaging and computational fluid dynamics (CFD) embryo-specific modeling. We focused on the heart outflow tract (OFT) region of day 3 embryos, and compared normal (control) conditions to conditions after performing an OFT banding intervention, which alters hemodynamics in the embryonic heart and vasculature. We found that hemodynamics and cardiac wall motion in the OFT are affected by banding in ways that might not be intuitive a priori. In addition to the expected increase in ventricular blood pressure, and increase blood flow velocity and, thus, wall shear stress (WSS) at the band site, the characteristic peristaltic-like motion of the OFT was altered, further affecting flow and WSS. Myocardial contractility, however, was affected only close to the band site due to the physical restriction on wall motion imposed by the band. WSS were heterogeneously distributed in both normal and banded OFTs. Our results show how banding affects cardiac mechanics and can lead, in the future, to a better understanding of mechanisms by which altered blood flow conditions affect cardiac development leading to congenital heart ...Continue Reading

References

Dec 1, 1992·Developmental Dynamics : an Official Publication of the American Association of Anatomists·V Hamburger, H L Hamilton
Jul 1, 1995·Physiological Reviews·P F Davies
May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Kimimasa TobitaBradley B Keller
Nov 5, 2003·Nature Biotechnology·James G Fujimoto
Jan 29, 2005·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Kimimasa TobitaBradley B Keller
May 2, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Jennifer L LucittiBradley B Keller
Jan 30, 2008·Medical & Biological Engineering & Computing·Robert E PoelmannBeerend P Hierck
Jul 29, 2008·TheScientificWorldJournal·Beerend P HierckRobert E Poelmann
Nov 28, 2008·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·A M DavisJ A Izatt
Apr 30, 2009·Journal of the Royal Society, Interface·C PoelmaJ Westerweel
Jan 20, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Courtney PeshkovskyDeborah Yelon
May 3, 2011·Journal of Biomedical Optics·Saba H SyedIrina V Larina
May 17, 2011·Computers & Structures·Aiping LiuSandra Rugonyi
Jun 15, 2012·Differentiation; Research in Biological Diversity·Chelsea L Gregg, Jonathan T Butcher
Jul 5, 2012·Biomechanics and Modeling in Mechanobiology·Sevan GoenezenSandra Rugonyi
May 28, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Liang ShiSandra Rugonyi
Aug 20, 2014·Frontiers in Physiology·Madeline Midgett, Sandra Rugonyi
Aug 29, 2014·Journal of the Royal Society, Interface·Madeline MidgettSandra Rugonyi
Sep 6, 2014·Frontiers in Physiology·Stephanie E LindseyHuseyin C Yalcin
May 1, 2012·IEEE Journal of Selected Topics in Quantum Electronics : a Publication of the IEEE Lasers and Electro-optics Society·Michael W JenkinsAndrew M Rollins
Sep 13, 2015·Biomechanics and Modeling in Mechanobiology·Sevan GoenezenSandra Rugonyi
Oct 16, 2015·Journal of the Royal Society, Interface·Madeline MidgettSandra Rugonyi
Feb 16, 2016·Journal of Cardiovascular Development and Disease·Vinal MenonJay D Potts

❮ Previous
Next ❯

Citations

Jan 26, 2018·Journal of Cardiovascular Development and Disease·Monique Y RennieSandra Rugonyi
Oct 16, 2015·Journal of the Royal Society, Interface·Madeline MidgettSandra Rugonyi
Feb 13, 2021·Journal of Cardiovascular Development and Disease·Huseyin Enes Salman, Huseyin Cagatay Yalcin
Apr 4, 2021·Journal of Cardiovascular Development and Disease·Maha AlserHuseyin C Yalcin

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.