Effect of ovarian steroids and diethylstilbestrol on the contractile responses of the human myometrium and intramyometrial arteries

European Journal of Pharmacology
A KostrzewskaS Batra

Abstract

Estriol, estradiol, progesterone and diethylstilbestrol in the concentration range of 0.2-40 microM inhibited the spontaneous contractions of the myometrium in a dose-dependent manner but the differences in IC50 values obtained with different hormones were not statistically significant. All these hormones caused a concentration-dependent inhibition of the K(+)-induced contraction. The IC50 values were lowest for diethylstilbestrol and highest for estriol. Vasopressin at concentrations of 1.5 x 10(-6) - 1.8 x 10(-3) U/ml stimulated myometrial contractions. These responses were also inhibited by ovarian steroids and diethylstilbestrol. The IC50 values for estriol and progesterone were significantly higher than for estradiol or diethylstilbestrol. The values for estriol and progesterone did not differ significantly. In the uterine arteries, which lacked spontaneous activity, ovarian steroids and diethylstilbestrol inhibited contractions induced by K+ depolarization. As with myometrium, the lowest effect was observed with estriol and the highest with diethylstilbestrol. A dose-dependent inhibition by all four hormones (0.2-40 microM) of vasopressin-induced contractile responses of the uterine arteries was observed. With the lowest ...Continue Reading

References

Jan 1, 1979·Pharmacology & Therapeutics·S J Segal, S S Koide
Feb 1, 1976·Endocrinology·A J HsuehJ H Clark
Jan 28, 1977·The Journal of Membrane Biology·R Deth, C van Breemen
Aug 1, 1977·Respiration Physiology·J Engelberg, J Radin
Aug 1, 1988·British Journal of Pharmacology·A KostrzewskaS Batra
Jan 1, 1988·Journal of Steroid Biochemistry·T G MuldoonJ Steinsapir
Jan 1, 1987·Gynecologic and Obstetric Investigation·S Batra, S Iosif
Oct 14, 1987·Biochemical and Biophysical Research Communications·A WallnöferU T Rüegg
Jul 1, 1985·Acta Physiologica Scandinavica·S MaigaardK E Andersson
Feb 1, 1984·Journal of Steroid Biochemistry·M Haukkamaa

❮ Previous
Next ❯

Citations

Sep 1, 1995·Obstetrics and Gynecology·J L RutgersJ Heiner
Jan 1, 1995·General Pharmacology·F M GoyacheB Cantabrana
Oct 17, 2002·Vascular Pharmacology·Charles R RosenfeldBlair E Cox
Sep 17, 2010·Planta medica·Christian W Gruber, Margaret O'Brien
Nov 1, 1996·The Journal of Clinical Investigation·C R RosenfeldR R Magness
Sep 29, 2011·Experimental and Molecular Pathology·Huiling LiuEddie Perkins
Oct 22, 2008·American Journal of Obstetrics and Gynecology·Nicole K RuddockRobert E Garfield
Dec 24, 2002·The Journal of Pharmacy and Pharmacology·Meili ZhangPeter K T Pang
Jun 24, 2020·International Journal of Molecular Sciences·Jin BaiDong-Bao Chen
Jul 19, 2000·American Journal of Physiology. Heart and Circulatory Physiology·C R RosenfeldB E Cox
Aug 25, 2005·Journal of Endocrinological Investigation·E DomaliI E Messinis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.