Effect of ovarian suppression with gonadotropin-releasing hormone agonist on glucose disposal and insulin secretion.

American Journal of Physiology. Endocrinology and Metabolism
Michael J TothPeter R Casson

Abstract

Several lines of evidence suggest that ovarian hormones influence glucose homeostasis, although their exact role in humans has not been clearly defined. In the present study, we sought to test the hypothesis that ovarian hormones regulate glucose homeostasis by examining the effect of pharmacologically induced ovarian hormone deficiency on glucose disposal and insulin secretion. Young, healthy women with regular menstrual patterns were studied during the follicular and luteal phases of their cycle at baseline and after 2 mo of treatment with gonadotropin-releasing hormone agonist (GnRHa; n = 7) or placebo (n = 6). Using hyperglycemic clamps, in combination with stable isotope-labeled (i.e., (13)C and (2)H) glucose tracers, we measured glucose disposal and insulin secretion. Additionally, we assessed body composition and regional fat distribution using radiologic imaging techniques as well as glucoregulatory hormones. Ovarian hormone suppression with GnRHa did not alter body composition, abdominal fat distribution, or thigh tissue composition. There was no effect of ovarian suppression on total, oxidative, or nonoxidative glucose disposal expressed relative to plasma insulin level. Similarly, no effect of ovarian hormone deficie...Continue Reading

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Citations

Jun 23, 2010·The Journal of Clinical Endocrinology and Metabolism·Peter R CassonMarjorie E Dixon
Jul 5, 2013·International Journal of Endocrinology and Metabolism·Sumika MatsuiMinoru Irahara
Mar 2, 2012·European Journal of Endocrinology·Kaspar SørensenAnders Juul
Feb 7, 2017·Annals of Pediatric Endocrinology & Metabolism·Jae Won YooHan Hyuk Lim
Dec 29, 2012·Reproductive Sciences·George AngelidisIoannis E Messinis
Mar 1, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sumika MatsuiMinoru Irahara

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