Effect of oxandrolone therapy on adult height in Turner syndrome patients treated with growth hormone: a meta-analysis

International Journal of Pediatric Endocrinology
Nicole M Sheanon, Philippe F Backeljauw

Abstract

Turner syndrome is a chromosomal abnormality in which there is complete or partial absence of the X chromosome. Turner syndrome effects 1 in every 2000 live births. Short stature is a cardinal feature of Turner Syndrome and the standard treatment is recombinant human growth hormone. When growth hormone is started at an early age a normal adult height can be achieved. With delayed diagnosis young women with Turner Syndrome may not reach a normal height. Adjuvant therapy with oxandrolone is used but there is no consensus on the optimal timing of treatment, the duration of treatment and the long term adverse effects of treatment. The objective of this review and meta-analysis is to examine the effect of oxandrolone on adult height in growth hormone treated Turner syndrome patients. Eligible trials were identified by a literature search using the terms: Turner syndrome, oxandrolone. The search was limited to English language randomized-controlled trials after 1980. Twenty-six articles were reviewed and four were included in the meta-analysis. A random effects model was used to calculate an effect size and confidence interval. The pooled effect size of 2.0759 (95 % CI 0.0988 to 4.0529) indicates that oxandrolone has a positive effec...Continue Reading

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Citations

Feb 14, 2018·The Journal of Clinical Endocrinology and Metabolism·Karen O KleinNelly Mauras
Jun 23, 2018·The Journal of Clinical Endocrinology and Metabolism·Shanlee M DavisJudith L Ross
Oct 11, 2019·Archives of Sexual Behavior·Lauren A MorrisRachel A Ross
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Jan 23, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jaroslav GalbaPeter Mikuš
Mar 19, 2021·Journal of the Endocrine Society·Maria G VogiatziJudith L Ross
Nov 5, 2019·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Trang N LeMichael S Stalvey

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