Effect of oxatomide on experimental allergic rhinitis in guinea pigs

Japanese Journal of Pharmacology
T KaiseK Ohmori

Abstract

We have investigated the effect of oxatomide, an antiallergic agent, on experimental allergic rhinitis in sensitized guinea pigs. Oxatomide (1 and 10 mg/kg, p.o.) significantly inhibited the sneeze response and nasal rubbing after antigen challenge. Oxatomide (10 and 30 mg/kg) reduced the increase in nasal vascular permeability induced by the antigen-antibody reaction. The decreases in nasal cavity volume caused by nasal mucosal swelling 10 min, 30 min and 6 hr after antigen challenge were significantly inhibited by oxatomide (30 mg/kg). These results indicate that oxatomide inhibits the experimental allergic rhinitis in guinea pigs.

References

Oct 1, 1992·The Journal of Allergy and Clinical Immunology·M V White, M A Kaliner
Jan 1, 1988·International Archives of Allergy and Applied Immunology·H ManabeS Yoshida
Jul 11, 1985·The New England Journal of Medicine·R M NaclerioL M Lichtenstein
Sep 1, 1994·The Journal of Allergy and Clinical Immunology·N TeradaK Togawa

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Citations

Jul 23, 2005·Pharmacology·Takashi SakairiMasafumi Yaguchi
Jul 17, 2008·International Immunopharmacology·Prashant C BahekarRajamannar Thennati

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