Effect of oxidant stress on calcium signaling in vascular endothelial cells

Free Radical Biology & Medicine
S J ElliottW P Schilling

Abstract

The endothelial cell is recognized as a critical modulator of blood vessel tone and reactivity. This regulatory function of endothelial cells occurs via synthesis and release of diffusible paracrine substances which induce contraction or relaxation of adjacent vascular smooth muscle. In response to stimulation by blood-borne agonists such as bradykinin or histamine, the endothelial cell utilizes cytosolic ionic Ca2+ as a trigger in the transduction of the stimulatory signal into a paracrine response. Considerable evidence has accumulated to indicate that various forms of biologically important oxidant stress alter vascular function in an endothelium-dependent manner. Further, oxidant stress is known to alter the mechanisms which govern Ca2+ homeostasis in the endothelial cell. Recently, we have described a model in which the oxidant tert-butylhydroperoxide is utilized to examine the effects of oxidant stress on Ca(2+)-dependent signal transduction in vascular endothelial cells. In this model, three temporal phases are evident and consist of (1) inhibition of the agonist-stimulated Ca2+ influx pathway, (2) inhibition of receptor-activated release of Ca2+ from internal stores and elevation of resting cytosolic free Ca2+ concentra...Continue Reading

References

Mar 1, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·K Shinohara, K R Tanaka
Jul 28, 1978·Biochemical and Biophysical Research Communications·J R Babson, D J Reed
Jan 1, 1992·The American Journal of Physiology·R J DolorA R Whorton
Aug 15, 1991·Archives of Biochemistry and Biophysics·K K WangT H Kuo
Jan 1, 1992·The American Journal of Physiology·P G PhillipsM F Tsan
Jan 15, 1991·Biochemistry·A SamuniJ B Mitchell
May 15, 1991·Biochemical Pharmacology·A J Kettle, C C Winterbourn
May 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M A ShatosJ C Hoak
Jan 1, 1991·Physiological Reviews·E Carafoli
May 1, 1990·Archives of Biochemistry and Biophysics·R B MooreV N Mankad
Nov 1, 1990·Archives of Biochemistry and Biophysics·S D Prabhu, G Salama
Aug 1, 1987·Journal of Applied Physiology·L JornotA F Junod
Nov 1, 1987·Pflügers Archiv : European journal of physiology·K TakedaH Stoeckel
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R Bicknell, B L Vallee
Jan 1, 1989·Pediatric Research·S P Andreoli
Jun 15, 1989·The Biochemical Journal·A L SavageB R Martin
Oct 1, 1989·The American Review of Respiratory Disease·T A Brock, E L Capasso
Jul 1, 1989·Trends in Pharmacological Sciences·S OrreniusP Nicotera
Aug 15, 1989·Biochimica Et Biophysica Acta·S R Kristensen
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L J IgnarroG Chaudhuri
Apr 15, 1988·Biochemical and Biophysical Research Communications·J HirosumiH Orimo
Nov 17, 1986·Biochimica Et Biophysica Acta·N M Scherer, D W Deamer
Mar 1, 1986·Journal of Applied Physiology·E R BlockL C Garg

❮ Previous
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Citations

Jun 1, 1994·Free Radical Biology & Medicine·A BarchowskyK P Chepenik
Nov 1, 1995·Free Radical Biology & Medicine·S J Elliott, S K Koliwad
Mar 3, 2004·Archives of Biochemistry and Biophysics·Suzanne L Iverson, Sten Orrenius
Feb 14, 2002·Molecular Immunology·Gennady Ermak, Kelvin J A Davies
Jan 1, 1997·Free Radical Biology & Medicine·Y J SuzukiA Sevanian
Jul 29, 1998·Free Radical Biology & Medicine·M MoutetJ Chaudière
Sep 1, 1999·Free Radical Biology & Medicine·J CortijoE J Morcillo
Feb 22, 2001·The Journal of Nutritional Biochemistry·R F.P. BertoloS A. Atkinson
Jan 1, 1994·Critical Reviews in Food Science and Nutrition·B HennigE A Decker
Aug 1, 1995·Journal of Autonomic Pharmacology·J Marín, M A Rodríguez-Martínez
Nov 8, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Mordecai P BlausteinW Gil Wier
Dec 6, 2006·Micron : the International Research and Review Journal for Microscopy·María Prado Figueroa, Julio Santiago Contreras
Dec 14, 2004·Free Radical Biology & Medicine·Yun-Sook KimSylvain Doré
Jul 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M C MartínezF J Romero
Jun 21, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Anna K BrzezinskaWilliam M Chilian
Jan 1, 1995·Scandinavian Journal of Thoracic and Cardiovascular Surgery·J StarkopfJ Samarütel
Mar 27, 2004·American Journal of Physiology. Cell Physiology·Brian J WisnoskeyWilliam P Schilling
Apr 20, 2017·American Journal of Respiratory Cell and Molecular Biology·Sunit SinglaRoberto F Machado
Jul 18, 2002·Journal of Pineal Research·L PoganR Sauvé
May 18, 1999·The American Journal of Physiology·D M HallC V Gisolfi
Oct 12, 1999·The American Journal of Physiology·J M PatelE R Block
Jun 24, 2000·Endothelium : Journal of Endothelial Cell Research·D A SchuschkeF N Miller
Mar 27, 1998·Biochemical Pharmacology·E WieslanderR Brattsand
Oct 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S Hyslop, G De Nucci
Dec 2, 2008·Microvascular Research·Adel Boueiz, Paul M Hassoun
Sep 9, 2009·Free Radical Biology & Medicine·Henry Jay Forman

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