PMID: 9165294Jan 1, 1997Paper

Effect of oxidative stress by iron on 4-hydroxynonenal formation and proliferative activity in hepatomas of different degrees of differentiation

Free Radical Biology & Medicine
A HammerR J Schaur

Abstract

It has been shown previously that oxidative stress by ferrous iron in vitro leads to an inhibition of proliferation of murine ascites tumour cells in vivo. This effect is associated with increased lipid peroxidation in terms of formation of the highly reactive aldehyde 4-hydroxynonenal (HNE), which has been shown to inhibit the proliferation of numerous tumours and to induce differentiation. It was the purpose of this article to study the occurrence and metabolism of HNE and its inducibility by oxidative stress in hepatomas of different degrees of differentiation to find further evidence for a possible role of HNE in proliferation and/or differentiation, because it is known that in hepatoma cells with a very low degree of differentiation basal lipid peroxidation is hardly detectable, while in normal hepatocytes the basal level of thiobarbituric acid reactive substances (TBArS) is rather high. MH1C1 hepatoma cells and Yoshida AH-130 hepatoma cells were chosen as highly differentiated and poorly differentiated tumour cells, respectively, and rat hepatocytes served as a control for normal liver phenotype. Ferrous histidinate (Fe/His) did not have a cytotoxic effect on Yoshida and MH1C1 cells, as measured by the LDH release test. I...Continue Reading

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Citations

Aug 9, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Jean-Louis NanoPatrick Rampal
Jun 23, 2010·Biochemistry·Pankaj ChaudharyYogesh C Awasthi
Mar 7, 2001·Antioxidants & Redox Signaling·M ParolaM U Dianzani
Nov 19, 2008·Journal of Clinical Biochemistry and Nutrition·Noriko Noguchi
Oct 18, 2015·Toxicology and Applied Pharmacology·Sharad S SinghalSanjay Awasthi
Jul 30, 2005·Journal of Cellular Biochemistry·Paolo BergamoMauro Rossi
Apr 22, 2010·IUBMB Life·Jaya P Gnana-PrakasamVadivel Ganapathy
Aug 4, 2004·Free Radical Biology & Medicine·Yogesh C AwasthiSanjay Awasthi
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Sep 14, 2006·Fundamental & Clinical Pharmacology·K B DakshayaniM Mohamed Essa
Nov 5, 2014·Antioxidants & Redox Signaling·Giuseppina BarreraFabrizio Gentile
Jun 10, 2016·Cell Death & Disease·E Panieri, M M Santoro
May 8, 2020·The Kurume Medical Journal·Sumita BanerjeePallav Singhal
May 1, 2000·Alternatives to Laboratory Animals : ATLA·F MoriniM Ferro
Apr 29, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Raquel MateosLaura Bravo
Aug 28, 2018·Chemical Reviews·Saba ParvezYimon Aye

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