PMID: 3744169Jun 1, 1986Paper

Effect of oxybutynin hydrochloride on isolated smooth muscles (ileum, urinary bladder and urethra)

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
Y AidaT Kasama

Abstract

Effects of oxybutynin hydrochloride on isolated smooth muscle were investigated in preparations of isolated rabbit bladder body, bladder base, collum vesicae and urethra. ACh produced a marked contraction of the preparation from the bladder body and produced no response in the collum vesicae and the urethra; however, NE caused a marked contraction of the preparations from the collum vesicae and the urethra and relaxation in the bladder body. Oxybutynin and papaverine hardly had any effect on these preparations. Effects of oxybutynin on the contractile response of the isolated ileum or urinary bladder of rabbit, guinea pig and rat in comparison with atropine, papaverine, flavoxate and other drugs were investigated. The responsibility of these preparations to ACh were approximately 100 times higher in the ileum than in the urinary bladder. Oxybutynin showed a competitive inhibition to contractile response induced by ACh in the ileum and urinary bladder, whose potency was about 1/7-1/10 that of atropine. In the ileum of rats which were treated with oxybutynin orally at a dose of 1, 10 or 100 mg/kg for 60 days, the response to ACh in the preparations of the animals treated by 100 mg/kg were decreased, but the anticholinergic action...Continue Reading

Citations

Jun 13, 1998·International Journal of Urology : Official Journal of the Japanese Urological Association·H KikukawaS Ueda
Jul 1, 1997·International Journal of Urology : Official Journal of the Japanese Urological Association·Y SasakiK Kimura

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