Effect of Oxygen Flow on Aerosol Delivery From a Nebulizer With a Holding Chamber

Respiratory Care
Rania M SarhanMohamed E Abdelrahim

Abstract

A new holding chamber was designed to be used with a vibrating mesh nebulizer to increase the total inhalable dose for patients. It facilitates intermittent and continuous nebulization as well as the optional supply of supplemental oxygen via a T-piece with a mouthpiece adapter. This study aimed to evaluate the effect of oxygen introduction in the new holding chamber on aerosol delivery using a vibrating mesh nebulizer. The study was divided into 2 parts. First, the total inhalable dose of 1 mL of a respirable solution (nominal dose of 5,000 μg-salbutamol) was determined using a breathing simulator set to provide a tidal volume of 500 mL, a breathing frequency of 15 breaths/min, and an inspiratory:expiratory ratio of 1:1 for adults as a quiet-breathing pattern. Three experimental nebulizer setups were used: a vibrating mesh nebulizer with the holding chamber and oxygen set at 6 L/min, a vibrating mesh nebulizer with the holding chamber and no oxygen, and a vibrating mesh nebulizer with the T-piece. Aerodynamic particle size characterizations were determined using cooled Andersen cascade impaction at an inhalation flow of 15 L/min. Second, we performed an in vivo study involving 12 healthy non-smoking subjects (6 female) who wer...Continue Reading

Citations

Mar 5, 2020·Expert Opinion on Drug Delivery·Mario CazzolaPaola Rogliani
Dec 6, 2020·International Journal of Clinical Practice·Basma M E MohamedRaghda R S Hussein
Dec 7, 2020·International Journal of Clinical Practice·Yasmin M MadneyMohamed E A Abdelrahim
Jun 13, 2021·International Journal of Clinical Practice·Mona A AbdelrahmanHaitham Saeed

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