Effect of oxytocin on spontaneous electrical and mechanical activities in pregnant human myometrium

American Journal of Obstetrics and Gynecology
T KawarabayashiH Sugimori

Abstract

Spontaneous intracellular electrical activity and contraction of pregnant human myometrium were recorded by the single sucrose-gap method, and the effects of oxytocin on the muscle were studied. In pregnant human myometrium at term, both plateau and spike types of action potentials were observed. All contractions were well synchronized with each action potential. Oxytocin, 10(-2) U/ml, potentiated spontaneous contractions by enhancing the plateau part of action potentials; spike-type configuration became plateau. When extracellular ionized calcium was removed, spontaneous activities disappeared, while 10(-2) U/ml of oxytocin could evoke action potentials and contractions but these were smaller than those of the controls. Spontaneous activities also disappeared when ionized calcium was increased to 5 mmol/L, but oxytocin evoked plateau potentials and contractions remarkably. Diltiazem (ionized calcium antagonist), 10(-6) gm/ml, suppressed the spontaneous activity, but oxytocin evoked action potentials and contractions in high frequency, the duration of the action potential being short and the contraction being small. In the presence of 10(-4) gm/ml of diltiazem, 10(-2) U/ml of oxytocin could not evoke any action potentials but d...Continue Reading

References

Jan 1, 1977·The Japanese Journal of Physiology·T Osa, T Kawarabayashi
May 12, 1976·Pflügers Archiv : European journal of physiology·J Mironneau
Jun 1, 1974·Canadian Journal of Biochemistry·M O Marshall, M Kates

❮ Previous
Next ❯

Citations

Apr 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A S ChanS H Rolbin
Nov 7, 2012·BMC Medical Physics·Patricio S La RosaArye Nehorai
Jul 27, 1999·The Journal of Physiology·G A KnockP I Aaronson
Mar 1, 1993·American Journal of Obstetrics and Gynecology·T KawarabayashiH Sugimori
Oct 1, 2009·American Journal of Obstetrics and Gynecology·Stéphanie CorriveauJean-Charles Pasquier
Jan 1, 1988·Annals of the New York Academy of Sciences·K E Andersson
Dec 19, 2020·Acta Physiologica·Manasi MalikSarah K England
Jul 1, 1994·The American Journal of Physiology·S E SzalK G Morgan
May 11, 2021·Taiwanese Journal of Obstetrics & Gynecology·Pin LiHuishu Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Obstetrics and Gynecology
Y InoueH Kuriyama
The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Marie-Ève Roy-LacroixJean-Charles Pasquier
Methods and Findings in Experimental and Clinical Pharmacology
C NacitarhanM Erman
© 2021 Meta ULC. All rights reserved