Effect of ozone pre-conditioning on redox activity in a rat model of septic shock

Toxicology Mechanisms and Methods
Dailén GuancheYaima Alonso

Abstract

The confirmed advantageous effects of oxygen/ozone therapy in several clinical conditions stimulated experimental studies on effects of the therapy in induced septic shock. This study researches the influence of Ozone Oxidative Pre-conditioning (OOP) in unbalance between pro-oxidant and antioxidant activity generated in liver and lung during a process of sepsis. The study was conducted on male rats. Sepsis was induced by intraperitoneal injection of fecal material and pre-treatment with ozone/oxygen mixture was administered before fecal material injection. Activities of catalase, glutathione peroxide, and superoxide dismutase were measured, as well as conjugated dienes (CD) and thiobarbituric acid reactive substances (TBARS) were estimated. The results demonstrated that OOP not cause oxidative damage. It reduced levels of pro-oxidant biomarkers in lung and liver, with decreased total pro-oxidant activity and elevated total antioxidant activity from a system for diagnosis of oxidative stress in both tissues. These results suggest that OOP protected liver and lung for oxidative stress in septic shock.

References

Mar 15, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Minami, H Yoshikawa
Jun 1, 1977·Scandinavian Journal of Clinical and Laboratory Investigation·G Friman
Apr 1, 1992·Journal of Applied Physiology·A LeonM Aubier
Jun 1, 1992·The American Review of Respiratory Disease·C ShindohG Supinski
Jul 1, 1990·The American Review of Respiratory Disease·J BoczkowskiM Aubier
Nov 1, 1984·Critical Care Medicine·K TakedaI Yoshiya
Jan 10, 1995·Archives of Biochemistry and Biophysics·D E TaylorC A Piantadosi
Sep 1, 1994·The Journal of Surgical Research·P W PerdueT Williams
Oct 1, 1996·Critical Care Medicine·H F GalleyN R Webster
Jun 6, 1998·Molecular and Cellular Biochemistry·S N Hussain
May 1, 1998·American Journal of Respiratory and Critical Care Medicine·K M KrauseM B Reid
May 30, 1998·Lancet·M E Astiz, E C Rackow
Oct 29, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·F J Kelly
Feb 10, 2000·Critical Care Medicine·C C WinterbournJ A Windsor
Jul 13, 2000·Critical Care Medicine·G MathiakR Rabinovici
Nov 20, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·S M Al-DalainO S León
Feb 28, 2002·Academic Psychiatry : the Journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry·Joel V. Oberstar
May 25, 2002·Archivos de bronconeumología·E Barreiro, S N A Hussain
May 29, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hussam AjamiehOlga Sonia Leon
Aug 7, 2002·Critical Care Medicine·José M Alonso de VegaLuis F Carbonell
Jan 23, 2003·British Journal of Anaesthesia·J MacdonaldN R Webster
Sep 13, 2003·Chest·David Di GiantomassoRinaldo Bellomo
Sep 19, 2003·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Valery N Bochkov, Norbert Leitinger
Mar 24, 2004·International Immunopharmacology·Victor M VictorMonica De la Fuente
Apr 23, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·H H AjamiehOlga Sonia León Fernández
Jun 19, 2004·Mediators of Inflammation·Velio Bocci
Nov 1, 2005·Epidemiology and Infection·A FaustiniUNKNOWN Regional Network of Laboratory Surveillance of Giardia Group
Apr 21, 2006·Archives of Medical Research·Velio Alvaro Bocci
Mar 1, 2007·Current Opinion in Critical Care·Samir G Sakka
Apr 21, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A GrzeszczukJ S Dumler

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Citations

Sep 25, 2012·Biogerontology·Nagwa Ibrahim ShehataAmira Abd-Elmonem Shaheen
Dec 3, 2014·Enfermedades infecciosas y microbiología clínica·José L Martín-BarrasaM Teresa Tejedor-Junco
Mar 17, 2015·The Journal of Surgical Research·Tunay KurtogluMehmet Boga

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