Effect of p75 neurotrophin receptor antagonist on disease progression in transgenic amyotrophic lateral sclerosis mice

Journal of Neuroscience Research
Bradley J TurnerSurindar S Cheema

Abstract

Neurotrophin level imbalances and altered p75 neurotrophin receptor (p75(NTR)) expression are implicated in spinal motor neuron degeneration in human and mouse models of amyotrophic lateral sclerosis (ALS). Recently, elevated reactive astrocyte-derived nerve growth factor (NGF) was linked to p75(NTR)-expressing motor neuron death in adult transgenic ALS mice. To test the role of NGF-dependent p75(NTR)-mediated signalling in ALS, we examined the effects of a cyclic decapeptide antagonist of p75(NTR) ligand binding by using neurotrophin-stimulated cell death assays and transgenic ALS mice. Murine motor neuron-like (NSC-34) cell cultures expressed full-length and truncated p75(NTR), tyrosine receptor kinase B (TrkB), and the novel neurotrophin receptor homolog-2 (NHR2) but were TrkA deficient. Accordingly, treatment of cells with NGF induced dose-dependent cell death, which was significantly blocked by the cyclic decapeptide p75(NTR) antagonist. Application of brain-derived neurotrophic factor, neurotrophin-3, or neurotrophin-4 to cultures increased cell proliferation, and such trophic effects were abolished by pretreatment with the tyrosine kinase inhibitor K-252a. Systemic administration of a modified cyclic decapeptide p75(NTR)...Continue Reading

References

Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·S RabizadehD E Bredesen
Dec 1, 1993·Molecular and Cellular Biology·H Matsushima, E Bogenmann
Oct 24, 1997·Archives of Dermatology·M Yaar, B A Gilchrest
Apr 22, 1999·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H J Stuerenburg, K Kunze
May 9, 2000·Journal of Neurochemistry·C J EggettP J Shaw
Jul 7, 2000·The Journal of Biological Chemistry·E J CoulsonP F Bartlett
Jun 2, 2001·The New England Journal of Medicine·L P Rowland, N A Shneider
Jan 5, 2002·The Journal of Biological Chemistry·Mina YaarBarbara A Gilchrest
Jan 5, 2002·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·K S LowryS S Cheema
Jan 22, 2003·The Journal of Investigative Dermatology·Vladimir A BotchkarevRalf Paus
Apr 12, 2003·Clinical and Experimental Pharmacology & Physiology·Simon S MurraySurindar S Cheema
Jun 6, 2003·Neuropathology and Applied Neurobiology·D Dawbarn, S J Allen
Jun 6, 2003·Cytokine & Growth Factor Reviews·Shahrooz Rabizadeh, Dale E Bredesen
Jun 13, 2003·Neuroreport·Patrick WeydtThomas Möller
Sep 26, 2003·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·B M KüstJ C V M Copray
Oct 14, 2003·Experimental Neurology·Jianmin ZhangFred J Roisen
Feb 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christine E PaulPhilip A Barker
Mar 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Simon S MurrayMoses V Chao

❮ Previous
Next ❯

Citations

Oct 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Marcelo R Vargas, Jeffrey A Johnson
Oct 1, 2011·Journal of Biomedicine & Biotechnology·Kunihiro Sakuma, Akihiko Yamaguchi
Jun 21, 2011·PloS One·Jesse A SolomonMazen J Hamadeh
May 23, 2015·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Renaid B KimCassie S Mitchell
Jan 26, 2013·Pharmacology & Therapeutics·Shelley J AllenNikunj K Patel
Dec 26, 2006·Molecular and Cellular Neurosciences·Marco DomeniconiMoses V Chao
Feb 16, 2007·Neurobiology of Disease·Michael Benatar
Sep 29, 2006·The European Journal of Neuroscience·Mariana PeharLuis Barbeito
Aug 16, 2008·The European Journal of Neuroscience·Nathan C StamAnthony J Hannan
Jun 14, 2006·Xenotransplantation·Stephen J M SkinnerRobert B Elliott
Jul 11, 2006·Journal of Neuroscience Methods·Mary-Louise RogersRobert A Rush
Oct 11, 2005·Physical Medicine and Rehabilitation Clinics of North America·B Jane Distad, Michael D Weiss
Aug 30, 2005·Brain Research. Molecular Brain Research·Elisabetta BabettoLavinia Cantoni
Feb 26, 2015·The Journal of Comparative Neurology·Kevin S SmithMary-Louise Rogers
Apr 17, 2016·Brain : a Journal of Neurology·Sandrine Delbary-GossartMichael S Beattie
Jun 1, 2016·Frontiers in Cellular Neuroscience·Blandine Madji HounoumHélène Blasco
Dec 7, 2006·Journal of Cellular Physiology·William J Brackenbury, Mustafa B A Djamgoz
Sep 28, 2007·Journal of Neuroscience Research·Dusan MatusicaRobert A Rush
Feb 27, 2020·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Melissa Diane ArmstrongKerri Lynn Schellenberg
Feb 24, 2017·Neuronal Signaling·Amrita Pathak, Bruce D Carter
Dec 3, 2020·Cell Reports·Johnathan Cooper-KnockPamela J Shaw
Feb 11, 2021·Journal of Synchrotron Radiation·Ginevra Begani ProvincialiAlessia Cedola
Nov 9, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Catarina Miranda-LourençoMaria J Diógenes
Oct 9, 2021·Essays in Biochemistry·Tobias MollPamela J Shaw

❮ Previous
Next ❯

Related Concepts

Related Feeds

ALS: Genetics

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

ALS: Genetics

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating genetic alterations in this genetically heterogeneous disorder.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.