Effect of PAF-acether antagonists on active anaphylactic mouse paw edema

C Z AmorimB B Vargaftig


A new model of active anaphylactic reaction in mice was developed. The edematogenic reaction appeared 5 min after the intraplantar injection of ovalbumin, peaked at 30 min after the antigenic challenge, and decreased thereafter. Using the non-steroidal, anti-inflammatory agents indomethacin and aspirin, we found that cyclooxygenase products do not participate in the reaction. In contrast, vasoactive amines appear to be involved, because meclizine and methysergide reduced the edema. Dexamethasone, BW755C, LY 171883 and WEB 2170 effectively interfered with the edematogenic reaction, which suggests that lipid mediators such as leukotrienes and PAF play a role in the active anaphylactic response.


Sep 1, 1979·The Journal of Pharmacy and Pharmacology·S H Ferreira
Jan 1, 1990·British Journal of Pharmacology·M G HenriquesB B Vargaftig
Apr 1, 1987·British Medical Bulletin·B B Vargaftig, P G Braquet
Jan 1, 1986·International Archives of Allergy and Applied Immunology·S KanetaM Mitsuya
May 1, 1988·The Journal of Allergy and Clinical Immunology·P J BarnesC P Page
Jun 8, 1984·Journal of Immunological Methods·S KanetaM Mitsuya

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May 19, 1993·European Journal of Pharmacology·C Z AmorimB B Vargaftig
May 23, 1994·European Journal of Pharmacology·C Zuany-AmorimB B Vargaftig

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Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.