PMID: 2209152Oct 1, 1990Paper

Effect of PAF-acether inhalation on nonspecific bronchial reactivity and adrenergic response in normal and asthmatic subjects

R J HoppR G Townley


Bronchial hyperreactivity, although recognized as a hallmark of asthma, is not totally understood. Mast cell-derived mediators, including histamine, have been shown to cause immediate bronchoconstriction, but until recently, no single mediator has been shown to induce prolonged changes in airway reactivity. Recent reports indicate PAF-acether (PAF) can induce increased nonspecific bronchial reactivity in normal subjects but not in asthmatics. We sought to elucidate the role of PAF in airway hyperreactivity by comparing the effect of inhaled PAF on methacholine and isoproterenol airway responsiveness in six nonasthmatic and six asthmatic subjects. Neither nonspecific airway reactivity nor isoproterenol responsiveness was changed following PAF inhalation in the nonasthmatic subjects in the six days following PAF. Asthmatics had increased airway responsiveness to methacholine at two hours post-PAF, which did not persist. Responsiveness to isoproterenol did not change in the asthmatic subjects. Additional evaluation of the role of PAF in causing changes in airway reactivity is warranted.


May 1, 1988·The Journal of Allergy and Clinical Immunology·P J BarnesC P Page
Nov 1, 1987·The American Review of Respiratory Disease·A H RubinR Patterson
Dec 1, 1987·The Journal of Allergy and Clinical Immunology·R J HoppR G Townley
Nov 1, 1985·The Journal of Allergy and Clinical Immunology·B L LaubeR R Rosenthal


Jun 1, 1992·British Journal of Clinical Pharmacology·M M NieminenH Vapaatalo
Oct 3, 2002·American Journal of Respiratory and Critical Care Medicine·Ulrike GehringJoachim Heinrich
Oct 13, 2004·American Journal of Respiratory and Critical Care Medicine·Toyoko ArimotoRonald P Mason
Dec 25, 2004·American Journal of Respiratory and Critical Care Medicine·John W HollingsworthDavid A Schwartz

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