Effect of Pain and Mild Cognitive Impairment on Mobility

Journal of the American Geriatrics Society
Caroline A SchepkerJonathan F Bean

Abstract

To examine the effect of pain and mild cognitive impairment (MCI)-together and separately-on performance-based and self-reported mobility outcomes in older adults in primary care with mild to moderate self-reported mobility limitations. Cross-sectional analysis. Academic community outpatient clinic. Individuals aged 65 and older in primary care enrolled in the Boston Rehabilitative Impairment Study in the Elderly who were at risk of mobility decline (N=430). Participants with an average score greater than three on the Brief Pain Inventory (BPI) were defined as having pain. MCI was defined using age-adjusted scores on a neuropsychological battery. Multivariable linear regression models assessed associations between pain and MCI, together and separately, and mobility performance (habitual gait speed, Short Physical Performance Battery), and self-reports of function and disability in various day-to-day activities (Late Life Function and Disability Instrument). The prevalence of pain was 34% and of MCI was 42%; 17% had pain only, 25% had MCI only, 17% had pain and MCI, and 41% had neither. Participants with pain and MCI performed significantly worse than all others on all mobility outcomes (P<.001). Participants with MCI only or pa...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Mar 22, 2000·The Clinical Neuropsychologist·A M ShapiroJ Brandt
Mar 23, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Alan M JetteJacqueline Ashba
Mar 23, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Stephen M HaleyJacqueline Ashba
Mar 26, 2004·The Journal of Pain : Official Journal of the American Pain Society·Gabriel TanBilal F Shanti
Sep 3, 2004·Journal of the American Geriatrics Society·Stephen P SayersRoger A Fielding
Mar 15, 2006·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Debra K WeinerSusan Lieber
Apr 5, 2007·Nature Protocols·Christopher R Bowie, Philip D Harvey
May 17, 2008·Journal of the American Geriatrics Society·Joe VergheseRichard B Lipton
Nov 26, 2009·JAMA : the Journal of the American Medical Association·Suzanne G LeveilleJonathan F Bean
Aug 11, 2010·Archives of Neurology·Teresa BuracchioJeffrey Kaye
Sep 21, 2013·JAMA : the Journal of the American Medical Association·Cynthia J Brown, Kellie L Flood
Apr 26, 2014·JAMA : the Journal of the American Medical Association·Steven R CummingsLuigi Ferrucci
May 7, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Mette M PedersenJonathan F Bean

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Citations

Apr 26, 2019·The Medical Journal of Australia·Emily YouNicola T Lautenschlager
Jun 4, 2019·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Milan ChangOlof Gudny Geirsdottir
Oct 30, 2019·Health Technology Assessment : HTA·Louise M AllanClaire Bamford
Oct 2, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yurun CaiTongjian You
Oct 12, 2021·Frontiers in Neuroscience·Xueying ZhangChan Chen

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