PMID: 9662942Jul 15, 1998Paper

Effect of pamidronate on clinical symptoms and bone metabolism in fibrous dysplasia and McCune-Albright syndrome

Medizinische Klinik
J Pfeilschifter, R Ziegler

Abstract

Patients with fibrous dysplasia and the McCune-Albright syndrome which is characterized by additional endocrine dysfunctions, such as pubertas precox, suffer from a regional impairment in the differentiation of osteoblasts that is acquired during early embryogenesis and results in fibrous bone lesions. These lesions may cause bone deformities, fractures and chronical pain in the affected skeletal regions. We here report about our experience with a systemic treatment of the bisphosphonate pamidronate. We treated 3 patients with fibrous dysplasia and 5 patients with McCune-Albright syndrome over a cumulative period of 37 patient-years. In all patients who suffered from painful lesions, intravenous infusions of 60 mg pamidronate resulted in an improvement of pain that lasted up to 6 months. In 2 patients we also observed a reduction in the size of some of the osteolytic lesions. Side effects were limited to asymptomatical fever and a small decline in total serum calcium within the physiological limits during the infusions. Pamidronate appears to be an effective and well tolerable treatment option for patients with fibrous dysplasia.

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Citations

Jun 8, 2001·Journal of Pediatric Endocrinology & Metabolism : JPEM·W ZumkellerM Nagel
Jun 29, 2002·Journal of Pediatric Orthopedics. Part B·Caroline ChebliMichael T Collins
Oct 3, 2002·Clinical Orthopaedics and Related Research·Wudbhav N SankarJohn P Dormans
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Oct 8, 2004·The Journal of the American Academy of Orthopaedic Surgeons·Selene G ParekhRichard D Lackman
Mar 1, 2007·Journal of Children's Orthopaedics·Arabella I Leet, Michael T Collins
Sep 10, 2011·The Clinical Journal of Pain·Mark J WinstonUri S Alon
Jan 19, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Francis H Glorieux, Frank Rauch
Jan 17, 2014·Journal of Children's Orthopaedics·Greg GaskiJohn R Kean

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