PMID: 18198636Jan 18, 2008Paper

Effect of panax quinquefolius saponin on insulin sensitivity in patients of coronary heart disease with blood glucose abnormality

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
Ying ZhangYu-Ying Liu

Abstract

To investigate the effect of panax quinquefolius saponin(PQS) on blood glucose, blood lipid and insulin sensitivity in patients of coronary heart disease (CHD) with blood glucose abnormality (BGA). Eighty-four patients of CHD with BGA, namely CHD patients with impaired fasting glucose (IFG), or impaired glucose tolerance (IGT), or type 2 diabetes mellitus (T2DM), were randomly assigned to the PQS group (43 cases) and the control group (41 cases), all were treated with routine Western medicine, but to patients in the PQS group PQS was given orally for 4 successive weeks in addition. Levels of fasting plasma glucose (FPG), fasting insulin (FINS), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) were detected both before and after treatment, and insulin sensitive index (ISI) as well as the insulin resistance index and function of beta cells of homostasis model (Homa-IR and Homa-beta) were calculated accordingly. After treatment, FPG decreased predominantly in both groups (P < 0.01), and the decrement in the PQS group showed a greater trend (25.80 +/- 12.72) % vs (20.89 +/- 12.17) %, but with no statistical significance; no obvious change in levels ...Continue Reading

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.