PMID: 8593942Mar 1, 1996Paper

Effect of pancreas transplantation on free fatty acid metabolism in uremic IDDM patients

Diabetes
L LuziG Pozza

Abstract

To assess the effect of pancreas transplantation on free fatty acid (FFA) and glucose metabolism, we studied seven uremic IDDM patients (HbA1c 9.1%), nine IDDM patients after combined kidney-pancreas transplantation (HbA1c 5.8%), seven patients with chronic uveitis (HbA1c 5.6%), and nine normal control subjects (HbA1c 5.5%) by means of the [3(- 3)H]glucose and [1(-14)C]palmitate infusion techniques combined with indirect calorimetry and euglycemic insulin clamp. In the postabsorptive state, pancreas-transplant patients had similar plasma glucose and FFA concentrations and non-statistically different rates of hepatic glucose production (HGP) and FFA turnover, while demonstrating a reduced rate of FFA oxidation (42 +/- 5 vs. 73 +/- 10 micromol x m-2 x min-1; P < 0.05) compared with control subjects. After 180 min of tracer equilibration, all subjects underwent a low-dose (100 min, 8 mU x m-2 x min-1) followed by a high-dose (100 min, 40 mU x m-2 x min-1) euglycemic insulin infusion. During insulin infusion, pancreas-transplant patients showed a greater inhibition of FFA concentration (609 +/- 76 to 58 +/- 15 micromol/l) compared with healthy subjects (681 +/- 90 to 187 +/- 25 micromol/l; P < 0.01 vs. pancreas-transplant patients)...Continue Reading

Citations

Mar 17, 2001·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·K RieneckK Bendtzen
Oct 12, 2011·Annals of Nutrition & Metabolism·María-Eugenia FrigoletMartha Tamez González
Feb 15, 1997·The Journal of Clinical Investigation·L LuziV Mazzaferro
Jul 24, 1998·Clinical Chemistry and Laboratory Medicine : CCLM·R GarnotelP Gillery
Sep 11, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Cristina HernándezRafael Simó
Apr 23, 1999·Journal of Basic and Clinical Physiology and Pharmacology·J W Kolaczynski, J F Caro
Sep 16, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Gang MiaoHikaru Matsuda

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