PMID: 3562903Dec 30, 1986

Effect of pancreatic polypeptide on the motility of the guinea-pig small intestine in vitro

Regulatory Peptides
P HolzerG Leb


The effect of porcine pancreatic polypeptide (PP) on the motor activity of the longitudinal and circular muscles of the guinea-pig isolated small intestine was investigated. PP (0.2-20 nM) inhibited cholinergic contractions of the longitudinal muscle in response to electrical field stimulation, the maximal effect being a 30% reduction of the contraction amplitude. Carbachol-induced contractions of the longitudinal muscle were not affected by PP (10 nM). PP (0.3-30 nM) also inhibited reflex contractions of the circular muscle elicited by balloon distension and recorded orally to the site of distension; the maximal effect was a 80% reduction of the reflex contraction. In contrast, carbachol-induced contractions of the circular muscle remained unaltered by PP (10 nM). It was further found that PP (10 and 100 nM) enhanced the threshold intraluminal pressure at which peristaltic waves were triggered. All these effects of PP appeared to be transient. Taken together, these data indicate that PP does not act on intestinal smooth muscle but can modulate the activity of certain enteric neurones which are involved in the regulation of intestinal motility.


Jul 20, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·P Holzer, F Lembeck
Jan 1, 1977·Scandinavian Journal of Gastroenterology·S GustavssonF Nilsson
Jul 16, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·M Costa, J B Furness
Feb 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·M CostaJ C Bornstein
Jan 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·M CostaC M Humphreys
Jul 1, 1985·Peptides·T L O'DonohueD A DiMaggio
Mar 1, 1967·British Journal of Pharmacology and Chemotherapy·M D Gershon
Jun 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·P HolzerJ Donnerer
Nov 1, 1983·Canadian Journal of Physiology and Pharmacology·K E HallN E Diamant
May 22, 1981·European Journal of Pharmacology·M ToniniA Crema
Dec 1, 1958·British Journal of Pharmacology and Chemotherapy·E BülbringO B Saxby


Related Concepts

Intestinal Motility
Cavia porcellus
Intestines, Small
Neuropeptide Y Like Immunoreactive Peptide
Pancreatic Prohormone

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