Effect of pancuronium bromide on the adrenergic reactivity of the isolated rat vas deferens

European Journal of Pharmacology
A Quintana


Pancuronium bromide (10(-7) to 10(-4) M) failed to produce contraction of the isolated rat vas deferens. Also, no contractions were seen when the animals were pretreated with an MAO inhibitor (iproniazid 80 mg/kg, p.o.). On the other hand, pancuronium bromide (10(-6) to 10(-4) M) produced 1.62- to 2.65-fold increases in the sensitivity of the vas deferens to noradrenaline. This rules out an indirect adrenergic effect in this preparation and suggests an inhibitory effect on catecholamine uptake.


Nov 1, 1975·The Journal of Pharmacy and Pharmacology·A D IvankovichB Zahed
Dec 1, 1976·British Journal of Anaesthesia·J S DomenechJ S Oroz
Jan 1, 1973·British Journal of Anaesthesia·D A Nightingale, G H Bush
Nov 1, 1970·British Journal of Anaesthesia·G SmithA A Spence
Jan 1, 1973·Acta Anaesthesiologica Scandinavica·A NanaM Domokos
Nov 1, 1970·British Journal of Pharmacology·L L Iversen, P J Salt

Related Concepts

Smooth Muscle
Norepinephrine, (+, -)-Isomer
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Vas Deferens Structure
Rats, Laboratory

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