PMID: 4611Apr 1, 1976

Effect of para-aminohippurate on renal glutamine metabolism in the rat

The Journal of Pharmacology and Experimental Therapeutics
H G PreussP S Shim

Abstract

After para-aminohippurate (PAH) infusion into rats, urine pH decreased and urine ammonium excretion increased. Because augmented urine flow and decreased urine pH could not explain entirely the enhanced ammonium excretion, an increased ammonia production was postulated as a contributing influence. This was supported by the in vitro findings that PAH could increase slice ammoniagenesis from glutamine. The ability of PAH to stimulate ammoniagenesis in vitro was attributed to enhanced phosphate-dependent glutaminase activity. We conclude that PAH infusions at certain concentrations in vivo can alter ammonium excretion through increased renal ammonia production. The latter may be secondary to enhanced phosphate-dependent glutaminase activity.

Related Concepts

Aerobiosis
Aminohippuric Acids
Ammonia
Glutamic Acids
Phosphate-Activated Glutaminase
D-Glutamine
Hydrogen-Ion Concentration
Kidney
Lactates
Urination

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