Effect of parathyroid hormone on cardiac function in rats with cardiomyopathy

Experimental and Therapeutic Medicine
Gang-Yong WuGang-Jun Zong

Abstract

The present study investigated the role of parathyroid hormone (PTH) in non-ischemic cardiomyopathy (CM) and its underlying mechanism. A total of 30 Sprague-Dawley male rats were randomly divided into a control group (n=6) and an experimental group (n=24). To induce CM in the rats of the experimental group, 2 mg/kg Adriamycin (ADR) was administered intraperitoneally with 5 equal injections every third day followed by 5 weekly injections resulting in a cumulative dose of 20 mg/kg. Following establishment of the model, rats in the experimental group were subdivided into a PTH-untreated CM group that received daily normal saline subcutaneous injections for 7 days and three treated CM groups that received daily subcutaneous injections of 5, 10, or 20 µg/kg of recombinant PTH for 7 days. Rats in the control group accordingly received intraperitoneal and subcutaneous injections of normal saline. Blood sample analysis revealed that B-type natriuretic peptide (BNP), troponin T, C-reactive protein (CRP), creatinine and phosphorus concentrations were increased in the PTH-untreated CM group compared with that in the control group, whereas PTH and calcium concentrations were decreased. Administration of PTH dose-dependently decreased BNP, ...Continue Reading

References

Apr 16, 1998·Cardiovascular Research·K D Schlüter, H M Piper
Dec 13, 2000·European Journal of Heart Failure·K TeraokaA Yamashina
Mar 2, 2006·JAMA : the Journal of the American Medical Association·Dietlind ZohlnhöferUNKNOWN REVIVAL-2 Investigators
May 12, 2006·American Journal of Physiology. Cell Physiology·A A SelimP Divieti
Nov 24, 2006·Basic Research in Cardiology·Ute SeelandMichael Böhm
Feb 5, 2009·Basic Research in Cardiology·Giovanni MonegoArnaldo Capelli
Mar 21, 2012·European Journal of Endocrinology·Ghada T BallaneGhada El-Hajj Fuleihan
Nov 16, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Selene CapitanioCecilia Marini
Feb 2, 2013·Endocrine, Metabolic & Immune Disorders Drug Targets·Hakan Altay, Yucel Colkesen
Aug 21, 2013·Cell Biology International·Shou-Tang WangZhan-Peng Yue
Jan 10, 2014·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Krishna J Rocha-SinghMichael R Jaff
Aug 20, 2014·The Journal of Clinical Endocrinology and Metabolism·Natalie E CusanoJohn P Bilezikian
May 14, 2016·Genetic Testing and Molecular Biomarkers·Gangyong WuGangjun Zong

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BETA
ELISA
Protein Assay

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SPSS

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