Effect of paricalcitol vs calcitriol on hemoglobin levels in chronic kidney disease patients: a randomized trial

PloS One
Eleonora RiccioAntonio Pisani

Abstract

Recent studies suggest that vitamin D deficiency represents an additional cofactor of renal anemia, with several mechanisms accounting for this relationship. In line with it, the administration of vitamin D or its analogues has been associated with an improvement of anemia. There are no data, however, about a direct effect of paricalcitol on hemoglobin (Hb) levels. Therefore, we conducted a study to determine whether paricalcitol, compared to calcitriol, improves anemia in patients with chronic kidney disease (CKD). In this randomized trial 60 CKD patients stage 3b-5 and anemia (Hb levels: 10-12.5 g/dL) were assigned (1:1) to receive low doses of calcitriol (Group Calcitriol) or paricalcitol (Group Paricalcitol) for 6 months. All the patients had normal values of plasma calcium, phosphorus and PTH, a stable iron balance, and normal values of C-Reactive Protein. The primary endpoint was to evaluate the effects of the two treatments on Hb levels; the modifications in 24hr-proteinuria (UProt) were also evaluated. A significant Group x Time interaction effect was observed in the longitudinal analysis of Hb levels (F(1,172)=31.4, p<0.001). Subjects in Paricalcitol experienced a significant monthly increase of Hb levels equal to +0.1...Continue Reading

Associated Clinical Trials

Jan 15, 2013·Eleonora Riccio

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Citations

Dec 23, 2015·Assay and Drug Development Technologies·Hermann A M Mucke
Sep 29, 2015·Current Opinion in Endocrinology, Diabetes, and Obesity·Ellen M Smith, Vin Tangpricha
Aug 10, 2020·The Journal of Trauma and Acute Care Surgery·Camille G AppleAlicia M Mohr

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Clinical Trials Mentioned

NCT01768351

Software Mentioned

Statistical Package for Social Sciences ( SPSS )

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