PMID: 489162Aug 1, 1979Paper

Effect of parity regimen on the rate of occurrence of mammary tumors in A, C3H, and RIII mice

International Journal of Cancer. Journal International Du Cancer
D H Moore, J A Holben

Abstract

The occurrence rates of mammary tumors as affected by breeding regimen (early in life, late, continuous, or not at all) in A, RIII, and C3H mice were observed. The response to the breeding regimen was different in each of the three strains. The C3H stock was affected least, although the tumor occurrence rate was slower in virgins. In both A and RIII, only one litter at puberty resulted in the tumors occurring over the greatest age range; and in RIII mice, the occurrence rate and the mean tumor age were similar to those of the virgins. Normal continuous breeding caused the earliest tumors in all three strains, although the RIII mice, breeding after 18 weeks of age also caused very early tumors. The response of RIII strain to parity variations was more like that of humans than was the response of either of the other strains. Removal of the milk-transmitted virus from these strains by foster-nursing resulted in vastly different mammary tumor occurrence rates, the quantitative changes being different in each mouse strain.

References

Oct 1, 1976·Journal of the National Cancer Institute·D H MooreJ Charney
May 15, 1979·International Journal of Cancer. Journal International Du Cancer·D H MooreJ B Sheffield
Nov 27, 1971·Lancet·J F Fraumeni, R W Miller
Jan 1, 1973·Journal of the National Cancer Institute·B MacMahonJ Brown
Feb 1, 1969·American Journal of Epidemiology·G K Tokuhata
Sep 30, 1958·Annals of the New York Academy of Sciences·J J BITTNER

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Citations

Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L PaulingC Tsao
Nov 1, 1985·Antimicrobial Agents and Chemotherapy·H F AcevedoM Pardo
Mar 15, 1980·International Journal of Cancer. Journal International Du Cancer·R NusseG Röpcke

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